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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Behrens, M. | en |
| dc.contributor.author | Papadopoulos, G. K. | en |
| dc.contributor.author | Moustakas, A. | en |
| dc.contributor.author | Smart, M. | en |
| dc.contributor.author | Luthra, H. | en |
| dc.contributor.author | David, C. S. | en |
| dc.contributor.author | Taneja, V. | en |
| dc.date.accessioned | 2015-11-24T19:12:00Z | - |
| dc.date.available | 2015-11-24T19:12:00Z | - |
| dc.identifier.issn | 1529-0131 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20998 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Arthritis/*genetics/*immunology | en |
| dc.subject | Collagen Type II/immunology/metabolism | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Female | en |
| dc.subject | *Genetic Predisposition to Disease | en |
| dc.subject | HLA-DQ Antigens/*genetics | en |
| dc.subject | HLA-DQ beta-Chains | en |
| dc.subject | Haplotypes/genetics | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Membrane Glycoproteins/*genetics | en |
| dc.subject | Mice | en |
| dc.subject | Mice, Transgenic | en |
| dc.subject | Models, Molecular | en |
| dc.subject | Severity of Illness Index | en |
| dc.title | Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1002/art.30260 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21305521 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/art.30260/asset/30260_ftp.pdf?v=1&t=h0w0a7wb&s=5d4d0fd9dae94aea46702df6cf48584a7931a490 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | OBJECTIVE: Certain HLA class II alleles are associated with susceptibility to the development of arthritis. However, the development of arthritis in some persons carrying non-rheumatoid arthritis (RA)-associated alleles remains unexplained. An individual who is heterozygous for the DQA1 and DQB1 genes can express the DQ molecule in cis or trans heterodimers. In a cis heterodimer, the alpha-chain interacts with the beta-chain coded by the same chromosome, while in a trans heterodimer it interacts with the beta-chain on the other chromosome. In this study, we used a humanized mouse model of arthritis in an attempt to determine whether a trans heterodimer of 2 nonassociated alleles, DQB1*0601 and DQB1*0604, can predispose to arthritis. METHODS: DQB1*0601 and *0604 occur in linkage with DQA1*0103 and *0102, respectively. To understand the role of trans heterodimers, we generated DQB1*0604/DQA1*0103-transgenic mice lacking endogenous HLA class II molecules. RESULTS: Severe arthritis developed in the DQB1*0604/A1*0103-trangenic mice, and an antigen-specific response was generated in vitro. DQB1*0604/DQA1*0103 presented type II collagen-derived peptides that were not presented by the arthritis-resistant DQB1*0601 allele, suggesting that trans heterodimer molecules between 2 DQB1 and DQA1 molecules may result in the presentation of unique antigens and susceptibility to the development of arthritis. Molecular modeling of type II collagen peptides showed that DQB1*0604/DQA1*0103 shares a p4 pocket with the arthritis-susceptible DQB1*0302 allele, suggesting a critical role of the p4 and p9 pockets in susceptibility to arthritis. CONCLUSION: These results provide a possible explanation for the parental inheritance of nonsusceptibility alleles in some patients with RA and a mechanism by which they can predispose to the development of arthritis. | en |
| heal.journalName | Arthritis Rheum | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Behrens-2011-Trans heterodimer be.pdf | 263.07 kB | Adobe PDF | View/Open Request a copy |
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