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https://olympias.lib.uoi.gr/jspui/handle/123456789/20996Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ioachim, E. E. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Kamina, S. A. | en |
| dc.contributor.author | Goussia, A. C. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T19:12:00Z | - |
| dc.date.available | 2015-11-24T19:12:00Z | - |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20996 | - |
| dc.rights | Default Licence | - |
| dc.subject | Breast/chemistry | en |
| dc.subject | Breast Neoplasms/*chemistry | en |
| dc.subject | Carcinoma, Ductal, Breast/chemistry | en |
| dc.subject | Carcinoma, Lobular/chemistry | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Ki-67 Antigen/analysis | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neoplasm Proteins/*analysis | en |
| dc.subject | Proliferating Cell Nuclear Antigen/analysis | en |
| dc.subject | Proto-Oncogene Proteins/analysis | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2/*analysis | en |
| dc.subject | Receptor, Epidermal Growth Factor/analysis | en |
| dc.subject | Receptor, erbB-2/analysis | en |
| dc.subject | Retinoblastoma Protein/analysis | en |
| dc.subject | Tumor Suppressor Protein p53/analysis | en |
| dc.subject | bcl-2-Associated X Protein | en |
| dc.title | Immunohistochemical expression of Bcl-2 protein in breast lesions: correlation with Bax, p53, Rb, C-erbB-2, EGFR and proliferation indices | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11205251 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | Expression of bcl-2 protein was investigated and correlated with Bax, p53 and Rb proteins, c-erbB-2, EGFR and the proliferation indices PCNA, Ki-67 and MIB1 as well as with the conventional clinicopathological parameters in 95 cases for breast cancer tissue and 20 cases of benign hyperplastic lesions. Bcl-2 and Bax proteins immunoreactivity was detected in normal, hyperplastic and neoplastic breast epithelium. Expression of the bcl-2 protein was detected in 40% of carcinomas (> 10% positive neoplastic cells) and 85.2% of the benign hyperplastic lesions. Bax protein expression was detected in 8.1% of the carcinomas and 5.3% in the hyperplastic group. Rb and p53 proteins were detected in 75.5% and 45.5% of carcinomas. No relationship was observed between bcl-2 expression and patient's age, tumour size, tumour type and grade, lymph node status, Rb protein expression and proliferation indices. However, a strong positive relationship was detected between bcl-2 and Bax (p = 0.008), estrogen (ER) (p = 0.007) and progesterone receptors' (PgR) status (p = 0.0003). An inverse correlation with p53 protein (p = 0.004) was detected. Furthermore, a strong correlation was also observed between pRb and p53 (p = 0.001). The results indicate that in breast cancer bcl-2 protein expression may be under hormonal control. Since the expression is bcl-2 protein was inversely correlated with p53 protein expression, we suggest that bcl-2 may be related with favourable outcome in breast cancer. | en |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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