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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Goussia, A. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Peschos, D. | en |
| dc.contributor.author | Assimakopoulos, D. | en |
| dc.contributor.author | Vougiouklakis, T. | en |
| dc.contributor.author | Skevas, A. | en |
| dc.contributor.author | Agnantis, N. | en |
| dc.date.accessioned | 2015-11-24T19:11:59Z | - |
| dc.date.available | 2015-11-24T19:11:59Z | - |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20995 | - |
| dc.rights | Default Licence | - |
| dc.subject | Carcinoma in Situ/enzymology/metabolism/pathology | en |
| dc.subject | Carcinoma, Squamous Cell/enzymology/metabolism/pathology | en |
| dc.subject | Cathepsin D/*metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Laryngeal Neoplasms/*enzymology/metabolism/pathology | en |
| dc.subject | Papilloma/enzymology/metabolism/pathology | en |
| dc.subject | Precancerous Conditions/enzymology/metabolism/pathology | en |
| dc.title | Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10652592 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1999 | - |
| heal.abstract | Clinical studies in several tumour types have shown a strong correlation between cathepsin D expression and tumour progression. Immunohistochemical staining for cathepsin D (clone D13A) was performed in paraffin embedded-tissues from 39 invasive squamous cell carcinomas, 13 in situ carcinomas, 35 cases of dysplasia, 10 papillomas and 17 cases of keratosis. The association between cathepsin D expression and CD44, p53, Rb proteins and proliferation indices (Ki-67, PCNA) was assessed by univariate analysis. Cathepsin D was highly positive in the groups of carcinomas compared to other lesions (p < 0.0001). A statistically significant correlation of cathepsin D expression with CD44 expression was observed in invasive cancers (p = 0.037). The relationship of cathepsin D immunoreactivity with p53, Rb and proliferation indices was insignificant. The results show that cathepsin D is expressed in a higher proportion of cancerous lesions of the larynx than in non cancerous or premalignant lesions, a fact which suggests that cathepsin D may be involved in laryngeal tumour cell growth process. | en |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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