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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20975
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dc.contributor.authorStefanou, D.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorZioga, A.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorPapachristou, D. J.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:11:52Z-
dc.date.available2015-11-24T19:11:52Z-
dc.identifier.issn1066-8969-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20975-
dc.rightsDefault Licence-
dc.subjectCell Counten
dc.subjectDiagnosis, Differentialen
dc.subjectDysplastic Nevus Syndrome/*metabolism/pathologyen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectMelanoma/*metabolism/pathologyen
dc.subjectProto-Oncogene Proteins c-kit/*metabolismen
dc.subjectSkin Neoplasms/*metabolism/pathologyen
dc.subjectTumor Markers, Biological/metabolismen
dc.subjectVascular Endothelial Growth Factor A/*metabolismen
dc.titleImmunohistochemical expression of vascular endothelial growth factor (VEGF) and C-KIT in cutaneous melanocytic lesionsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15173918-
heal.identifier.secondaryhttp://ijs.sagepub.com/content/12/2/133.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractVascular endothelial growth factor (VEGF) and C-KIT are involved in tumor progression in several human neoplasms. The aim of the present study has been to investigate their immunohistochemical expression in melanocytic lesions. We examined 11 compound nevi, 12 dysplastic nevi, and 18 melanomas. Immunostaining for VEGF was observed only in melanomas; c-kit expression was detected in melanomas (higher in radial than in vertical growth phase) and in nevi (predominantly in the junctional component). Our data indicate that assessment of VEGF expression might aid in the differential diagnosis between dysplastic nevi and melanomas. Moreover, VEGF might be a candidate for targeted therapy. The loss of c-kit expression might contribute to melanoma progression.en
heal.journalNameInt J Surg Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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