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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mitselou, A. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Kitsou, E. | en |
| dc.contributor.author | Vougiouklakis, T. | en |
| dc.contributor.author | Zagorianakou, N. | en |
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Stefanaki, S. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T19:11:50Z | - |
| dc.date.available | 2015-11-24T19:11:50Z | - |
| dc.identifier.issn | 0258-851X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20968 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Carcinoma/*metabolism/pathology | en |
| dc.subject | Cell Division | en |
| dc.subject | Endometrial Hyperplasia/*metabolism/pathology | en |
| dc.subject | Endometrial Neoplasms/*metabolism/pathology | en |
| dc.subject | Endometrium/*metabolism/pathology | en |
| dc.subject | Female | en |
| dc.subject | *Fungal Proteins | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Ki-67 Antigen/metabolism | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neoplasm Staging | en |
| dc.subject | Proliferating Cell Nuclear Antigen/metabolism | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2/*metabolism | en |
| dc.subject | Receptor, erbB-2/metabolism | en |
| dc.subject | Receptors, Steroid/metabolism | en |
| dc.subject | Serine Endopeptidases/metabolism | en |
| dc.subject | Tumor Markers, Biological/metabolism | en |
| dc.subject | Tumor Suppressor Protein p53/metabolism | en |
| dc.subject | Tumor Suppressor Proteins/*metabolism | en |
| dc.title | Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices (Ki67, PCNA), tumor suppressor genes (p53, pRb), the oncogene c-erbB-2, sex steroid hormone receptors and other clinicopathological features, in normal, hyperplastic and neoplastic endometrium | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14598611 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2003 | - |
| heal.abstract | The bcl-2 gene codes for a protein which functions to inhibit apoptotic cell death, that involves an intrinsic normal cell death program. Bcl-2 overexpression was originally described in a follicular lymphoma, but more recently bcl-2 expression has been observed in a variety of other human neoplasms. Variation in the frequency of apoptosis in hormone-sensitive tissues, such as the endometrium, is known to occur as a result of hormonal changes in both physiological and pathological circumstances. In this study we examined bcl-2 protein expression in a total of 170 samples of endometrial tissues (18 proliferative endometrium, 14 secretory endometrium, 35 adenomatous hyperplasia and 103 carcinomas). The results were compared with p53, pRb and c-erbB-2 proteins expression, estrogen and progesterone receptors status, with the proliferative activity and with clinicopathological features. The expression of bcl-2 protein was lower in the group of carcinomas, when compared with the cases of adenomatous hyperplasia (p < 0.0001), normal proliferative (p < 0.0001) and secretory endometrium (p = 0.07). In normal proliferative endometrium bcl-2 expression was correlated with PCNA (p = 0.026) and in secretory endometrium it was correlated with ER status (p = 0.042). In hyperplasias, bcl-2 was correlated with PCNA (p = 0.019) and the PR (p = 0.007) expression. In carcinomas, decreased bcl-2 expression was associated with increased tumor grade (p = 0.04). A positive relationship between bcl-2 expression and pRb, as well as PCNA score (p = 0.014 and p = 0.001, respectively), was also found. These results indicate that bcl-2 expression may play a role in the inhibition of apoptosis in endometrial carcinoma and its expression seems to be associated with tumor differentiation and cell proliferation. | en |
| heal.journalName | In Vivo | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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