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dc.contributor.authorLetsas, K. P.en
dc.contributor.authorFrangou-Lazaridis, M.en
dc.contributor.authorSkyrlas, A.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.date.accessioned2015-11-24T19:11:49Z-
dc.date.available2015-11-24T19:11:49Z-
dc.identifier.issn1320-5463-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20965-
dc.rightsDefault Licence-
dc.subjectAdenoma/pathology/physiopathologyen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subject*Apoptosisen
dc.subjectCarcinoma, Papillary, Follicular/pathology/physiopathologyen
dc.subject*Cell Proliferationen
dc.subjectDNA-Binding Proteins/analysis/immunology/physiologyen
dc.subjectE2F1 Transcription Factor/analysis/immunology/physiologyen
dc.subjectFemaleen
dc.subjectGoiter/pathology/physiopathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProtein Precursors/analysis/immunology/physiologyen
dc.subjectRepressor Proteins/analysis/immunology/physiologyen
dc.subjectThymosin/analogs & derivatives/analysis/immunology/physiologyen
dc.subjectThyroid Diseases/*pathology/physiopathologyen
dc.subjectThyroid Gland/chemistry/cytology/*pathologyen
dc.subjectThyroid Neoplasms/*pathology/physiopathologyen
dc.subjectTranscription Factors/analysis/immunology/*physiologyen
dc.subjectTumor Suppressor Protein p53/analysis/immunology/physiologyen
dc.subjectTumor Suppressor Proteins/analysis/immunology/physiologyen
dc.subjectbcl-2-Associated X Protein/analysis/immunology/physiologyen
dc.titleTranscription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesionsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1111/j.1440-1827.2005.01899.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16271081-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1440-1827.2005.01899.x/asset/j.1440-1827.2005.01899.x.pdf?v=1&t=h0ouh9jg&s=020206b0ab2c0e4b24995167b123499ecf6b9dca-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractTranscription factors play an essential role in regulating both cell proliferation and programmed cell death. Proliferation and apoptosis-related transcription factor immunoexpression patterns were concomitantly investigated in tissue sections of normal thyroid, goiters, follicular adenomas and well-differentiated papillary and follicular carcinomas using antibodies against prothymosin alpha, E2F-1, p53, Bcl2, and Bax proteins. Proliferation and apoptotic indices were determined by Ki-67 immunoreactivity and the terminal deoxynucleotidyl transferase-mediated deoxy uridine triphosphate nick-end labeling technique, respectively. Prothymosin alpha and E2F-1 immunoexpression levels were found to be significantly elevated in well-differentiated carcinomas compared to adenomas, goiters and normal tissues (P < 0.05). Both proteins were directly correlated with the proliferation index (P < 0.05). E2F-1 was additionally correlated with the apoptotic index (P < 0.05). The majority of cases were negative for p53 staining. Positive Bcl2 immunostaining was detected in all thyroid histotypes. None of the normal tissues showed Bax immunoreactivity, while positive accumulation differed significantly between hyperplastic and neoplastic histotypes. Direct correlations were observed between prothymosin alpha and Bcl2 as well as between E2F-1 and Bax immunoexpression (P < 0.05). These data demonstrate that prothymosin alpha and E2F-1 are strongly involved in the proliferation processes of thyroid neoplasias. Furthermore, prothymosin alpha may promote cell survival through the Bcl2 anti-apoptotic pathway, while E2F-1-induced apoptosis via p53-independent pathways may be associated with transcriptional activation of bax pro-apoptotic gene.en
heal.journalNamePathol Inten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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