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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20962
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dc.contributor.authorDalekos, G. N.en
dc.contributor.authorManoussakis, M. N.en
dc.contributor.authorZervou, E.en
dc.contributor.authorTsianos, E. V.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:11:48Z-
dc.date.available2015-11-24T19:11:48Z-
dc.identifier.issn0014-2972-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20962-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAutoantibodies/blooden
dc.subjectFemaleen
dc.subjectHIV Seropositivity/complications/*immunology/*microbiologyen
dc.subjectHepacivirus/immunologyen
dc.subjectHepatitis Antibodies/blooden
dc.subjectHepatitis B Antibodies/blooden
dc.subjectHepatitis B Surface Antigens/blooden
dc.subjectHepatitis C Antibodiesen
dc.subjectHeroin Dependence/complications/*immunology/*microbiologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectReceptors, Interleukin-2/metabolismen
dc.titleImmunologic and viral markers in the circulation of anti-HIV negative heroin addictsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7684680-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2362.1993.tb00765.x/asset/j.1365-2362.1993.tb00765.x.pdf?v=1&t=h0ov8obl&s=9cd73934282a023bbd11ab93be992e7415f57db3-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1993-
heal.abstractTo assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleukin-2 receptors (sIL-2R). In addition, 28 anti-HCV positive patients comprising the disease control group, were also examined. Our results demonstrated a high prevalence of anti-HCV antibodies (61.7% and 90% with 1st and 2nd generation ELISA, respectively). Eighty-seven percent (87%) of the addicts positive for anti-HCV by the latter and 92.8% of the disease control patients, were also positive with 2nd generation recombinant immunoblot assay (RIBA-II). In 88.9% of anti-HCV positive addicts, antibody to C22-3 was the predominant (anti-C33c in 81.5%). Antibodies to C33c and C22-3 polypeptides were also more frequent in disease control group (92.8% and 85.7%, respectively). Anti-HCV antibodies were associated with increased transaminases (ALT or AST, P < 0.05), as well as with longer duration of addiction (P < 0.005). HBV infection markers (HBsAg, anti-HBc only and anti-HBs) were also present in the addicts (5%, 28.3% and 26.7%, respectively). Rheumatoid factors (RF) were detected in 36.7%, antinuclear antibodies (ANA) in 11.7%, antibodies (IgG and/or IgM) against cardiolipin (anti-CL) and double stranded DNA (anti-ds DNA) in 20% and 50%, respectively. RF, ANA, anti-CL and anti-dsDNA antibodies were also detected in the disease control group (32.1%, 89.3%, 28.5% and 28.5% respectively).(ABSTRACT TRUNCATED AT 250 WORDS)en
heal.journalNameEur J Clin Investen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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