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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20947
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dc.contributor.authorStefanis, N. C.en
dc.contributor.authorTrikalinos, T. A.en
dc.contributor.authorAvramopoulos, D.en
dc.contributor.authorSmyrnis, N.en
dc.contributor.authorEvdokimidis, I.en
dc.contributor.authorNtzani, E. E.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorStefanis, C. N.en
dc.date.accessioned2015-11-24T19:11:38Z-
dc.date.available2015-11-24T19:11:38Z-
dc.identifier.issn0006-3223-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20947-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectCarrier Proteins/*genetics/physiologyen
dc.subjectCognition/*physiologyen
dc.subjectDNA/geneticsen
dc.subjectGenotypeen
dc.subjectHaplotypesen
dc.subjectHumansen
dc.subjectIntelligence Testsen
dc.subjectLinkage Disequilibrium/geneticsen
dc.subjectMaleen
dc.subjectNeuregulin-1/genetics/physiologyen
dc.subjectNeuropsychological Testsen
dc.subjectPersonality Testsen
dc.subjectPhenotypeen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectPopulationen
dc.subjectRisken
dc.subjectSchizophrenia/*geneticsen
dc.subject*Schizophrenic Psychologyen
dc.subjectSchizotypal Personality Disorder/*genetics/*psychologyen
dc.titleImpact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population levelen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.biopsych.2006.11.015-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17336946-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0006322306014879/1-s2.0-S0006322306014879-main.pdf?_tid=666fa027bad64022ec05f75a2b8414bb&acdnat=1333363951_3394e3a6029e900b183a92513de96311-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractBACKGROUND: Aspects of cognitive function and schizotypy have been proposed as potential endophenotypes for schizophrenia. It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia. METHODS: We examined the potential impact of 18 single nucleotide polymorphisms (SNPs) within the DTNBP1, NRG1, DAOA/G32, and DAAO genes, on cognition and self-rated schizotypy, in a representative population of 2243 young male military conscripts. Single SNP and haplotype associations were evaluated. RESULTS: The DTNBP1 SNPs rs2619522 and rs760761 exhibited several single marker associations, the minor alleles being associated with lower attention capacity but also a decrease in positive and paranoid schizotypy scores. The DTNBP1 haplotype load had borderline associations with nonverbal IQ, paranoid schizotypy, and sustained attention. For individual NRG1 polymorphisms, isolated but weak signals of association were noted with sustained attention and working memory but not schizotypy. The risk allele of functional SNP8NRG243177 was associated with reduced spatial working memory capacity. An isolated effect of DAAO haplotype variability was noted on negative and disorganization schizotypy. No convincing association of DAOA/G32 variability was detected. CONCLUSIONS: The DTNBP1 and, less so, NRG1 and DAAO variants might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level.en
heal.journalNameBiol Psychiatryen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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