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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20898
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dc.contributor.authorPlumier, J. C.en
dc.contributor.authorKrueger, A. M.en
dc.contributor.authorCurrie, R. W.en
dc.contributor.authorKontoyiannis, D.en
dc.contributor.authorKollias, G.en
dc.contributor.authorPagoulatos, G. N.en
dc.date.accessioned2015-11-24T19:11:05Z-
dc.date.available2015-11-24T19:11:05Z-
dc.identifier.issn1355-8145-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20898-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectArterial Occlusive Diseases/genetics/metabolism/pathologyen
dc.subjectBrain Ischemia/*genetics/*metabolism/pathologyen
dc.subjectDisease Susceptibilityen
dc.subjectHSP70 Heat-Shock Proteins/analysis/*biosynthesis/*geneticsen
dc.subjectHippocampus/*blood supply/pathologyen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Transgenicen
dc.subjectNeurons/*pathologyen
dc.titleTransgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injuryen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9314603-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1997-
heal.abstractUsing transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral ischemia. Twenty-four hours after permanent occlusion of the middle cerebral artery, no difference in infarct area was detected between Hsp70-transgenic and non-transgenic mice. In the non-transgenic mice, many pyramidal neurons of the ipsilateral hippocampus were observed to be pyknotic. However, in all Hsp70-transgenic mice, hippocampal pyramidal neurons showed normal morphology and no evidence of pyknosis. This suggests that constitutive expression of Hsp70 reduces the extent of damage following permanent middle cerebral artery occlusion.en
heal.journalNameCell Stress Chaperonesen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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