Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20868
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dc.contributor.authorJung, J. M.en
dc.contributor.authorBruner, J. M.en
dc.contributor.authorRuan, S.en
dc.contributor.authorLangford, L. A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorKobayashi, T.en
dc.contributor.authorLevin, V. A.en
dc.contributor.authorZhang, W.en
dc.date.accessioned2015-11-24T19:10:46Z-
dc.date.available2015-11-24T19:10:46Z-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20868-
dc.rightsDefault Licence-
dc.subjectBrain/*metabolismen
dc.subjectBrain Neoplasms/genetics/*metabolism/pathologyen
dc.subjectCyclin-Dependent Kinase Inhibitor p21en
dc.subjectCyclins/genetics/*metabolismen
dc.subjectGene Deletionen
dc.subjectGlioma/genetics/*metabolism/pathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKi-67 Antigenen
dc.subjectNeoplasm Proteins/analysis/genetics/*metabolismen
dc.subjectNuclear Proteins/analysisen
dc.subjectTumor Markers, Biological/genetics/*metabolismen
dc.subjectTumor Suppressor Protein p53/genetics/metabolismen
dc.titleIncreased levels of p21WAF1/Cip1 in human brain tumorsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7478521-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1995-
heal.abstractThe cdk inhibitor p21WAF1/Cip1 (p21), which can be transcriptionally activated by p53, functions to block cell cycle progression. In this study, we analysed the expression of p21 in normal and reactive brain and in gliomas of various malignancy grades. Southern blotting showed no p21 gene deletion. Western blotting and immunohistochemical assay showed that the levels of p21 protein in normal and reactive brain tissue were very low; however, p21 was elevated in a majority of gliomas tested, regardless of their malignancy grades. In glioblastoma multiforme, marked elevation of p21 was observed in samples harboring either wild-type or mutant p53. But, in anaplastic astrocytomas, the level of p21 was not elevated in samples harboring mutant-type p53. Immunohistochemical staining of paraffin-embedded astrocytomas and glioblastomas showed that tumor cells and not contaminating normal cells were positive for p21. Therefore, overexpression of p21 appears to be an early event in the development of glial neoplasms and p53-dependent p21 expression appears to be tumor grade specific.en
heal.journalNameOncogeneen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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