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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20828
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dc.contributor.authorAntoniou, K.en
dc.contributor.authorPapathanasiou, G.en
dc.contributor.authorPapalexi, E.en
dc.contributor.authorHyphantis, T.en
dc.contributor.authorNomikos, G. G.en
dc.contributor.authorSpyraki, C.en
dc.contributor.authorPapadopoulou-Daifoti, Z.en
dc.date.accessioned2015-11-24T19:10:26Z-
dc.date.available2015-11-24T19:10:26Z-
dc.identifier.issn0166-4328-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20828-
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectAvoidance Learning/physiologyen
dc.subjectDepression/metabolismen
dc.subjectDopamine/*metabolismen
dc.subjectExploratory Behavior/*physiologyen
dc.subjectIndividualityen
dc.subjectMaleen
dc.subjectMaze Learning/*physiologyen
dc.subjectMemory/physiologyen
dc.subjectMotor Activity/*physiologyen
dc.subjectNeostriatum/metabolismen
dc.subjectPhenotypeen
dc.subjectPrefrontal Cortex/metabolismen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectRecognition (Psychology)/*physiologyen
dc.subjectSerotonin/*metabolismen
dc.titleIndividual responses to novelty are associated with differences in behavioral and neurochemical profilesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.bbr.2007.10.010-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18036673-
heal.identifier.secondaryhttp://ac.els-cdn.com/S016643280700544X/1-s2.0-S016643280700544X-main.pdf?_tid=7c346b7c1aa48e8f52437fd1053b868b&acdnat=1332942726_54bc2dbee8fdb63bb7e49c8a2ce7acaf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2008-
heal.abstractExperimental animals can be differentiated on the basis of their horizontal or vertical activity to high responders (HR) and low responders (LR) upon exposure to a novel environment. These individual differences have been associated with behavioral and neurobiological differences in a number of experimental procedures used for studying sensitivity to psychostimulants, anxiety, depression, and cognitive function. In the present study, we differentiated the rats to HR and LR based on their vertical activity upon exposure to a novel environment. Additionally, we ascertained whether HR and LR rats differ in a battery of tests such as passive avoidance (PA), object recognition (OR), and the water-maze (WM) that provide indices for cognitive function and the forced swim test (FST), an animal model of affective responsivity and antidepressant-like activity. Potential differences in neurochemical indices between the two phenotypes were also examined. HR rats displayed impaired non-spatial object recognition memory, but enhanced spatial performance, as compared to LR rats. FST induced "depressive-like" symptoms in both phenotypes that were differently manifested in HR versus LR rats. Neurochemical findings revealed distinct differences in serotonergic and dopaminergic activity in the striatum and the prefrontal cortex of HR as compared to LR rats. The above results show that HR and LR rats exhibit important differences in a battery of tests related to cognitive performance or affective responsivity, which may be associated with differences in certain neurobiological parameters.en
heal.journalNameBehav Brain Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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