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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20795
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dc.contributor.authorTzoulaki, I.en
dc.contributor.authorMurray, G. D.en
dc.contributor.authorLee, A. J.en
dc.contributor.authorRumley, A.en
dc.contributor.authorLowe, G. D.en
dc.contributor.authorFowkes, F. G.en
dc.date.accessioned2015-11-24T19:10:08Z-
dc.date.available2015-11-24T19:10:08Z-
dc.identifier.issn0195-668X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20795-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectArteritis/diagnosisen
dc.subjectBiological Markers/*metabolismen
dc.subjectBlood Viscosity/physiologyen
dc.subjectCell Adhesion Molecules/metabolismen
dc.subjectCross-Sectional Studiesen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectHemostasisen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPeripheral Vascular Diseases/*diagnosisen
dc.subjectProspective Studiesen
dc.subjectROC Curveen
dc.subjectRisk Factorsen
dc.titleInflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1093/eurheartj/ehl441-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17213229-
heal.identifier.secondaryhttp://eurheartj.oxfordjournals.org/content/28/3/354.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractAIMS: Recently, markers of inflammation, haemostasis, and blood rheology have received much attention as risk factors for coronary heart disease and stroke. However, their role in peripheral arterial disease (PAD) is not well established and some of them, including the pro-inflammatory cytokine interleukin-6 (IL-6), have not been examined before in prospective epidemiological studies. METHODS AND RESULTS: In the Edinburgh Artery Study, we studied the development of PAD in the general population and evaluated 17 potential blood markers as predictors of incident PAD. At baseline (1987), 1519 men and women free of PAD aged 55-74 were recruited. After 17 years, 208 subjects had developed symptomatic PAD. In analysis adjusted for cardiovascular risk factors and baseline cardiovascular disease (CVD), only C-reactive protein, fibrinogen, lipoprotein (a), and haematocrit [hazard ratio (95% CI) corresponding to an increase equal to the inter-tertile range 1.30 (1.08, 1.56), 1.16 (1.05, 1.17), 1.22 (1.04, 1.44), 1.22 (1.08, 1.38)] were significantly (P < 0.01) associated with PAD. However, these markers provided very little prognostic information for incident PAD to that obtained by cardiovascular risk factors and the ankle brachial index. Other markers including IL-6, intracellular adhesion molecule 1, d-dimer, tissue plasminogen activator antigen, and plasma and blood viscosities showed weak associations, which were considerably attenuated when CVD risk factors were accounted for. CONCLUSIONS: Our prospective data showed that several inflammatory, haemostatic, and rheological markers are associated with incident PAD; however, their clinical utility is likely to be limited. Future research is necessary to validate the importance of these biomarkers explicitly on PAD and to address the causality of the reported associations.en
heal.journalNameEur Heart Jen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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