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https://olympias.lib.uoi.gr/jspui/handle/123456789/20783Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Alexiou, G. A. | en |
| dc.contributor.author | Goussia, A. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Tsiouris, S. | en |
| dc.contributor.author | Ntoulia, A. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Voulgaris, S. | en |
| dc.contributor.author | Fotopoulos, A. D. | en |
| dc.date.accessioned | 2015-11-24T19:10:03Z | - |
| dc.date.available | 2015-11-24T19:10:03Z | - |
| dc.identifier.issn | 1860-2002 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20783 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | *Drug Resistance, Multiple | en |
| dc.subject | *Drug Resistance, Neoplasm | en |
| dc.subject | Female | en |
| dc.subject | Glioma/*metabolism/*pathology | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Organophosphorus Compounds/*pharmacokinetics | en |
| dc.subject | Organotechnetium Compounds/*pharmacokinetics | en |
| dc.subject | Phenotype | en |
| dc.subject | Tomography, Emission-Computed, Single-Photon | en |
| dc.title | Influence of glioma's multidrug resistance phenotype on (99m)Tc-tetrofosmin uptake | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s11307-010-0369-y | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20552283 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/fw0688k882855367/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2011 | - |
| heal.abstract | PURPOSE: Multidrug resistance (MDR) remains a major obstacle to successful chemotherapeutic treatment of cancer. Several chemotherapeutic and radiopharmaceutical agents are substrates of the pumps encoded by the MDR genes, and therefore, their accumulation is prevented. We evaluated in vivo whether [(99m)Tc]tetrofosmin ((99m)Tc-TF) uptake is influenced by the MDR profile of gliomas. PROCEDURES: Eighteen patients with histologically confirmed glioma were included in the study. Brain single-photon emission computed tomography by (99m)Tc-TF was performed within a week prior to surgical excision, and the expression of MRP5 was assessed by immunohistochemistry. Radiotracer accumulation was assessed by a semiquantitative method, calculating the lesion-to-normal uptake ratio. RESULTS: Using Spearman's rho analysis, we found no correlation between tracer uptake expressed as lesion-to-normal and MRP5 expression. There was a significant correlation between glioma aggressiveness as assessed by Ki-67/MIB-1 and MRP5 expression. CONCLUSION: The present data suggest that (99m)Tc-TF uptake is not influenced by glioma's MDR phenotype. Thus, (99m)Tc-TF constitutes a suitable radiotracer for imaging gliomas. | en |
| heal.journalName | Mol Imaging Biol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Alexiou-2011-Influence of glioma'.pdf | 238.79 kB | Adobe PDF | View/Open Request a copy |
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