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dc.contributor.authorDrosos, A. A.en
dc.contributor.authorTsifetaki, N.en
dc.contributor.authorTsiakou, E. K.en
dc.contributor.authorTimpanidou, M.en
dc.contributor.authorTsampoulas, C.en
dc.contributor.authorTatsis, C. K.en
dc.contributor.authorKotoulas, K.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.rightsDefault Licence-
dc.subjectAntirheumatic Agents/*therapeutic useen
dc.subjectArthritis, Rheumatoid/*drug therapy/*radiographyen
dc.subjectDisease Progressionen
dc.subjectLongitudinal Studiesen
dc.subjectMethotrexate/*therapeutic useen
dc.subjectMiddle Ageden
dc.subjectPenicillamine/therapeutic useen
dc.subjectProspective Studiesen
dc.titleInfluence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective studyen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractOBJECTIVE: To evaluate if methotrexate (MTX) can slow disease progression, as determined radiographically, in comparison to other disease modifying drugs in rheumatoid arthritis (RA) patients. MATERIALS AND METHODS: Pairs of hand and wrist radiographs from 30 patients treated with MTX and 30 treated with D-penicillamine (DP) were evaluated blindly and separately by two radiologists (A and B) using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The radiographs studied were obtained at the beginning and 5 years after therapy in both groups. RESULTS: A significantly greater worsening was found in the DP-treated patients (p = 0.025), as compared to MTX patients. Methotrexate showed a slower rate of disease progression than DP. Furthermore, in the MTX group 15 patients remained radiographically stable, 9 worsened and 6 were healed. In contrast, in the DP group 22 patients remained radiographically stable, 8 worsened and none improved. CONCLUSIONS: The rate of radiographic progression in RA patients was lower in MTX-treated patients compared to those treated with DP. Six patients showed radiological improvement after MTX treatment. Therefore, it seems that MTX could be considered a disease modifying drug.en
heal.journalNameClin Exp Rheumatolen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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