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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Thabet, M. A. | en |
| dc.contributor.author | Challa, A. | en |
| dc.contributor.author | Chan, W. | en |
| dc.contributor.author | Liu, F. | en |
| dc.contributor.author | Hintz, R. L. | en |
| dc.contributor.author | Chan, J. C. | en |
| dc.date.accessioned | 2015-11-24T19:09:40Z | - |
| dc.date.available | 2015-11-24T19:09:40Z | - |
| dc.identifier.issn | 0002-9513 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20730 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Blotting, Western | en |
| dc.subject | Carrier Proteins/metabolism | en |
| dc.subject | Female | en |
| dc.subject | Insulin-Like Growth Factor Binding Proteins | en |
| dc.subject | Insulin-Like Growth Factor I/genetics | en |
| dc.subject | Liver/metabolism | en |
| dc.subject | Nephrotic Syndrome/*blood/chemically induced/metabolism | en |
| dc.subject | Puromycin | en |
| dc.subject | RNA, Messenger/metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Sprague-Dawley | en |
| dc.subject | Receptors, Somatotropin/genetics/*metabolism | en |
| dc.subject | Somatomedins/*metabolism | en |
| dc.title | Insulin-like growth factor and growth hormone receptor in nephrotic rats | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7508192 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1994 | - |
| heal.abstract | In an attempt to elucidate the mechanism of growth retardation in the nephrotic syndrome, specific serum and hepatic growth factors were measured in Sprague-Dawley rats in which nephrotic syndrome was produced by administration of puromycin (1.5 mg.100 g body wt-1.day-1) for 12 days. On the 13th day, the results of these nephrotic animals were compared with those of an equal number of pair-fed and control animals: the mean dietary intake of the nephrotic group was 71% that of the control group (P < 0.001). Serum insulin-like growth factor (IGF) binding protein-3 was significantly reduced (P < 0.005) in the nephrotic rats, compared with the pair-fed and the control groups. Hepatic IGF-I mRNA in the nephrotic rats averaged 36% that of control (P < 0.001) and 46% that of the pair-fed animals (P < 0.001). Hepatic growth hormone receptor (GHr) mRNA in the nephrotic rats averaged 19% of that of the control (P < 0.001) and 27% of that of the pair-fed rats (P < 0.001). These results indicate that the growth retardation of the nephrotic rats may be associated with the significant decrease in IGF-I mRNA and reduction in GHr mRNA. | en |
| heal.journalName | Am J Physiol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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