1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20635
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKarcz-Kubicha, M.en
dc.contributor.authorAntoniou, K.en
dc.contributor.authorTerasmaa, A.en
dc.contributor.authorQuarta, D.en
dc.contributor.authorSolinas, M.en
dc.contributor.authorJustinova, Z.en
dc.contributor.authorPezzola, A.en
dc.contributor.authorReggio, R.en
dc.contributor.authorMuller, C. E.en
dc.contributor.authorFuxe, K.en
dc.contributor.authorGoldberg, S. R.en
dc.contributor.authorPopoli, P.en
dc.contributor.authorFerre, S.en
dc.date.accessioned2015-11-24T19:09:01Z-
dc.date.available2015-11-24T19:09:01Z-
dc.identifier.issn0893-133X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20635-
dc.rightsDefault Licence-
dc.subjectAdenosine/*analogs & derivatives/pharmacologyen
dc.subjectAmphetamine/pharmacologyen
dc.subjectAnimalsen
dc.subjectBehavior, Animalen
dc.subjectCaffeine/*administration & dosageen
dc.subjectCentral Nervous System Stimulants/*administration & dosageen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDrug Administration Schedule/veterinaryen
dc.subjectDrug Interactionsen
dc.subjectMaleen
dc.subjectMotor Activity/*drug effectsen
dc.subjectPhenethylamines/pharmacologyen
dc.subjectPurinergic P1 Receptor Agonistsen
dc.subjectPurinergic P1 Receptor Antagonistsen
dc.subjectRadioligand Assay/methodsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptor, Adenosine A2Aen
dc.subjectReceptors, Purinergic P1/*physiologyen
dc.subjectTheophylline/*analogs & derivatives/pharmacologyen
dc.subjectTime Factorsen
dc.subjectTriazines/pharmacokineticsen
dc.subjectTriazoles/pharmacokineticsen
dc.subjectTritium/pharmacokineticsen
dc.subjectXanthines/pharmacokinetics/pharmacologyen
dc.titleInvolvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administrationen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/sj.npp.1300167-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12700682-
heal.identifier.secondaryhttp://www.nature.com/npp/journal/v28/n7/pdf/1300167a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractThe involvement of adenosine A(1) and A(2A) receptors in the motor effects of caffeine is still a matter of debate. In the present study, counteraction of the motor-depressant effects of the selective A(1) receptor agonist CPA and the A(2A) receptor agonist CGS 21680 by caffeine, the selective A(1) receptor antagonist CPT, and the A(2A) receptor antagonist MSX-3 was compared. CPT and MSX-3 produced motor activation at the same doses that selectively counteracted motor depression induced by CPA and CGS 21680, respectively. Caffeine also counteracted motor depression induced by CPA and CGS 21680 at doses that produced motor activation. However, caffeine was less effective than CPT at counteracting CPA and even less effective than MSX-3 at counteracting CGS 21680. On the other hand, when administered alone in habituated animals, caffeine produced stronger motor activation than CPT or MSX-3. An additive effect on motor activation was obtained when CPT and MSX-3 were coadministered. Altogether, these results suggest that the motor-activating effects of acutely administered caffeine in rats involve the central blockade of both A(1) and A(2A) receptors. Chronic exposure to caffeine in the drinking water (1.0 mg/ml) resulted in tolerance to the motor effects of an acute administration of caffeine, lack of tolerance to amphetamine, apparent tolerance to MSX-3 (shift to the left of its 'bell-shaped' dose-response curve), and true cross-tolerance to CPT. The present results suggest that development of tolerance to the effects of A(1) receptor blockade might be mostly responsible for the tolerance to the motor-activating effects of caffeine and that the residual motor-activating effects of caffeine in tolerant individuals might be mostly because of A(2A) receptor blockade.en
heal.journalNameNeuropsychopharmacologyen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Karcz-Kubicha-2003-Involvement of adeno.pdf196.52 kBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons