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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20630
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dc.contributor.authorKaramanakos, P. N.en
dc.contributor.authorPappas, P.en
dc.contributor.authorMarselos, M.en
dc.date.accessioned2015-11-24T19:08:58Z-
dc.date.available2015-11-24T19:08:58Z-
dc.identifier.issn0166-4328-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20630-
dc.rightsDefault Licence-
dc.subject3,4-Dihydroxyphenylacetic Acid/metabolismen
dc.subject8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacologyen
dc.subjectAnimalsen
dc.subjectBehavior, Animal/drug effectsen
dc.subjectBody Temperature/drug effectsen
dc.subjectBrain/anatomy & histology/*metabolismen
dc.subjectBrain Chemistryen
dc.subjectChlorpheniramine/*pharmacologyen
dc.subjectChromatography, High Pressure Liquid/methodsen
dc.subjectDopamine/metabolismen
dc.subjectHistamine H1 Antagonists/pharmacologyen
dc.subjectHomovanillic Acid/metabolismen
dc.subjectHydroxyindoleacetic Acid/metabolismen
dc.subjectMaleen
dc.subjectMotor Activity/*drug effectsen
dc.subjectNorepinephrine/metabolismen
dc.subjectRatsen
dc.subjectRats, Wistar/*metabolismen
dc.subjectReceptor, Serotonin, 5-HT1A/*physiologyen
dc.subjectSerotonin/*metabolismen
dc.subjectSerotonin 5-HT1 Receptor Agonistsen
dc.subjectSerotonin Receptor Agonists/pharmacologyen
dc.subjectSpecies Specificityen
dc.subjectStatistics, Nonparametricen
dc.subjectTime Factorsen
dc.titleInvolvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptorsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14684260-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0166432803001931/1-s2.0-S0166432803001931-main.pdf?_tid=0e54be90cdf68320f664977d12f09410&acdnat=1333002316_6bd99aae4ecd3201a6784c48a9fb941b-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractAntihistamines, such as chlorpheniramine (CPA), are lipophilic agents which readily cross the blood-brain barrier, producing sedation in 10-25% of users. However, with excessive doses instead of sedation a stimulating action has been reported. The aim of the present study was to investigate the influence of CPA on the locomotor activity of the rat in relation to its effects on brain biogenic monoamines. Wistar rats were given CPA (40 mg/kg, i.p.) and locomotor activity was measured in a photocell cage. Body temperature was also monitored. In addition, in three brain subregions (striatum, hypothalamus, and midbrain), the levels of 5-HT, NA, DA, as well as their metabolites, were determined by HPLC. Soon after injection, CPA produced a significant increase in locomotor activity, while a hypothermic response was also induced. In striatum and hypothalamus, which are known to be rich in postsynaptic 5-HT1A receptors, we found a significant time-dependent increase of 5-HT, correlated with the clearly enhanced locomotor activity of the animals. On the contrary, in midbrain, where presynaptic 5-HT1A receptors are dominating, no changes could be detected in 5-HT. In all three brain regions measured, 5-HIAA levels were decreased. The levels of the other brain monoamines were only marginally affected. In support of a role in receptor specificity, pretreatment with the 5-HT1A receptor agonist 8-OH-DPAT (1.25 mg/kg, i.p., two times) or with the 5-HT(1A/B) receptor antagonist pindolol (30 mg/kg, i.p., two times), enhanced or blocked, respectively, the hyperlocomotion induced by CPA. These findings suggest that the central serotonergic system may play a key role in the locomotor stimulant effects of CPA in the rat. Moreover, this behavioral component of CPA seems to be primarily mediated via the postsynaptic 5-HT1A receptors.en
heal.journalNameBehav Brain Resen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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