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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20520
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dc.contributor.authorNaka, K. K.en
dc.contributor.authorPappas, K.en
dc.contributor.authorPapathanassiou, K.en
dc.contributor.authorPapamichael, N. D.en
dc.contributor.authorKazakos, N.en
dc.contributor.authorKanioglou, C.en
dc.contributor.authorMakriyiannis, D.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorLiveris, K.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorMichalis, L. K.en
dc.date.accessioned2015-11-24T19:08:21Z-
dc.date.available2015-11-24T19:08:21Z-
dc.identifier.issn1475-2840-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20520-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectBlood Pressure/drug effectsen
dc.subjectDiabetes Mellitus, Type 2/*complications/*drug therapyen
dc.subjectDiastoleen
dc.subjectEchocardiography, Doppleren
dc.subjectHeart Function Tests/drug effectsen
dc.subjectHumansen
dc.subjectHyperglycemia/complications/drug therapyen
dc.subjectHypoglycemic Agents/*administration & dosageen
dc.subjectInsulin Resistanceen
dc.subjectMiddle Ageden
dc.subjectSystoleen
dc.subjectThiazolidinediones/*administration & dosageen
dc.subjectTreatment Failureen
dc.subject*Ventricular Dysfunction, Left/complications/drug therapy/ultrasonographyen
dc.titleLack of effects of pioglitazone on cardiac function in patients with type 2 diabetes and evidence of left ventricular diastolic dysfunction: a tissue doppler imaging studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1186/1475-2840-9-57-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20863381-
heal.identifier.secondaryhttp://www.cardiab.com/content/pdf/1475-2840-9-57.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractBACKGROUND: Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on novel echocardiographic indices of left ventricular (LV) diastolic function in DM2 patients with LV diastolic dysfunction (LVDD). METHODS: Eighty-eight asymptomatic DM2 patients on metformin and/or sulfonylureas, aged 64.5 +/- 7.7 years, without known cardiovascular disease, with normal LV systolic function and evidence of LVDD were randomly assigned to pioglitazone 30 mg/day (n = 42) or an increase in dose of other oral agents (n = 39) for 6 months. All patients underwent transthoracic conventional and Tissue Doppler Imaging echocardiography at baseline and follow-up. The primary end-point was change in early diastolic velocity of the mitral annulus (E'). RESULTS: Improvement of glycaemic control was similar in the 2 groups. A significant difference (p < 0.05) between the 2 groups was found in the treatment-induced changes in fasting insulin, the insulin resistance index HOMA, HDL cholesterol, triglycerides, diastolic blood pressure (all in favor of pioglitazone) and in body weight (increase with pioglitazone). No significant changes were observed in any echocardiographic parameter in either group and did not differ between groups (p = NS for all). E' increased non-significantly and to a similar extent in both groups (p = NS). CONCLUSIONS: In asymptomatic DM2 patients with LVDD, the addition of pioglitazone to oral conventional treatment for 6 months does not induce any adverse or favorable changes in LV diastolic or systolic function despite improvements in glycaemic control, insulin sensitivity, lipid profile, and blood pressure.en
heal.journalNameCardiovasc Diabetolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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