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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20480
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dc.contributor.authorLangdahl, B. L.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorRalston, S. H.en
dc.contributor.authorTrikalinos, T. A.en
dc.contributor.authorBalcells, S.en
dc.contributor.authorBrandi, M. L.en
dc.contributor.authorScollen, S.en
dc.contributor.authorLips, P.en
dc.contributor.authorLorenc, R.en
dc.contributor.authorObermayer-Pietsch, B.en
dc.contributor.authorReid, D. M.en
dc.contributor.authorArmas, J. B.en
dc.contributor.authorArp, P.en
dc.contributor.authorBassiti, A.en
dc.contributor.authorBustamante, M.en
dc.contributor.authorHusted, L. B.en
dc.contributor.authorCarey, A. H.en
dc.contributor.authorPerez Cano, R.en
dc.contributor.authorDobnig, H.en
dc.contributor.authorDunning, A. M.en
dc.contributor.authorFahrleitner-Pammer, A.en
dc.contributor.authorFalchetti, A.en
dc.contributor.authorKarczmarewicz, E.en
dc.contributor.authorKruk, M.en
dc.contributor.authorvan Leeuwen, J. P.en
dc.contributor.authorMasi, L.en
dc.contributor.authorvan Meurs, J. B.en
dc.contributor.authorMangion, J.en
dc.contributor.authorMcGuigan, F. E.en
dc.contributor.authorMellibovsky, L.en
dc.contributor.authorMosekilde, L.en
dc.contributor.authorNogues, X.en
dc.contributor.authorPols, H. A.en
dc.contributor.authorReeve, J.en
dc.contributor.authorRenner, W.en
dc.contributor.authorRivadeneira, F.en
dc.contributor.authorvan Schoor, N. M.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T19:07:56Z-
dc.date.available2015-11-24T19:07:56Z-
dc.identifier.issn8756-3282-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20480-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBone Densityen
dc.subjectCase-Control Studiesen
dc.subjectCohort Studiesen
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectFemur Neck/metabolismen
dc.subjectFractures, Bone/geneticsen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectLumbar Vertebrae/metabolismen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectOsteoporosis/*genetics/metabolism/pathologyen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectSex Factorsen
dc.subjectSpinal Fractures/geneticsen
dc.subjectTransforming Growth Factor beta1/*geneticsen
dc.titleLarge-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.bone.2007.11.007-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18284942-
heal.identifier.secondaryhttp://ac.els-cdn.com/S8756328207008605/1-s2.0-S8756328207008605-main.pdf?_tid=179225f5d648aa1d020cc9c90390a88e&acdnat=1333363854_cbb9dfe8d45fa1c6480d107a3b6a303a-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2008-
heal.abstractINTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results. METHODS: We investigated associations between TGFB1 polymorphisms and BMD and fracture in the GENOMOS study: a prospective multicenter study involving 10 European research studies including a total of 28,924 participants. Genotyping was conducted for known TGFB1 polymorphisms at the following sites: G-1639-A (G-800-A, rs1800468), C-1348-T (C-509-T, rs1800469), T29-C (Leu10Pro, rs1982073), G74-C (Arg25Pro, rs1800471) and C788-T (Thr263Ile, rs1800472). These polymorphisms were genotyped prospectively and methodology was standardized across research centers. Genotypes and haplotypes were related to BMD at the lumbar sine and femoral neck and fractures. RESULTS: There were no significant differences in either women or men at either skeletal site for any of the examined polymorphisms with the possible exception of a weak association with reduced BMD (-12 mg/cm2) in men with the T-1348 allele (p<0.05). None of the haplotypes was associated with BMD and none of the polymorphisms or haplotypes significantly affected overall risk of fractures, however, the odds ratio for incident vertebral fracture in carriers of the rare T788 allele was 1.64 (95% CI: 1.09-2.64), p<0.05. CONCLUSIONS: This study indicates that polymorphic variation in the TGFB1 gene does not play a major role in regulating BMD or susceptibility to fractures. The weak associations we observed between the C-1348-T and lumbar spine BMD in men and between C788-T and risk of incident vertebral fractures are of interest but could be chance findings and will need replication in future studies.en
heal.journalNameBoneen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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