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https://olympias.lib.uoi.gr/jspui/handle/123456789/20419
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DC Field | Value | Language |
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dc.contributor.author | Karageorgou, M. | en |
dc.contributor.author | Vasiliou, V. | en |
dc.contributor.author | Nebert, D. W. | en |
dc.contributor.author | Marselos, M. | en |
dc.date.accessioned | 2015-11-24T19:07:17Z | - |
dc.date.available | 2015-11-24T19:07:17Z | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20419 | - |
dc.rights | Default Licence | - |
dc.subject | Aldehyde Dehydrogenase/*biosynthesis | en |
dc.subject | Animals | en |
dc.subject | Carcinogens/*pharmacology | en |
dc.subject | Drug Interactions | en |
dc.subject | Enzyme Induction/drug effects | en |
dc.subject | Hormones/*pharmacology | en |
dc.subject | Liver/*drug effects/enzymology/metabolism | en |
dc.subject | Male | en |
dc.subject | Methylcholanthrene/*pharmacology | en |
dc.subject | Rats | en |
dc.subject | Rats, Wistar | en |
dc.subject | Receptors, Aryl Hydrocarbon/metabolism | en |
dc.subject | Receptors, Cell Surface/*drug effects/metabolism | en |
dc.title | Ligands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthrene | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8849341 | - |
heal.identifier.secondary | http://ac.els-cdn.com/0006295295020853/1-s2.0-0006295295020853-main.pdf?_tid=c5e9512aa1c5c4b50f1cfb8ac59d3ceb&acdnat=1332743108_9ef1a5ef327d6d1754e56f623536ee4b | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 1995 | - |
heal.abstract | Using six ligands that bind to four different receptors in the nuclear steroid/thyroid hormone superfamily, we have examined the effects of these chemicals on induction of the cytosolic aldehyde dehydrogenase (ALDH3c) activity by 3-methylcholanthrene (3MC) in rat liver and uterus. In contrast to negligible activities in the untreated rat, ALDH3c enzyme activities are induced after a single dose of 3MC. Hepatic ALDH3c induction is decreased 60% to 90% when 3MC is administered together with any of the following ligands: estradiol, testosterone, progesterone, hydrocortisol, diethylstilbestrol, or tamoxifen. None of these same doses of chemicals, administered alone, affects ALDH3c enzyme activity. In addition, when these ligands are injected 2 days after 3MC, no changes are observed in liver or uterus ALDH3c induction. These results suggest that ligands that bind to different receptors in the nuclear steroid/thyroid hormone superfamily might inhibit the ALD3H3c induction process by polycyclic aromatic hydrocarbons; the molecular mechanism(s) of this inhibitory effect is not yet understood. | en |
heal.journalName | Biochem Pharmacol | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Karageorgou-1995-Ligands of four rece.pdf | 575.73 kB | Adobe PDF | View/Open Request a copy |
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