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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20306
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dc.contributor.authorBai, M.en
dc.contributor.authorVlachonikolis, J.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorDimou, S.en
dc.contributor.authorNicolaides, C.en
dc.contributor.authorStefanaki, S.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:06:09Z-
dc.date.available2015-11-24T19:06:09Z-
dc.identifier.issn0893-3952-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20306-
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectBiological Markers/analysisen
dc.subjectCell Cycle Proteins/*biosynthesisen
dc.subjectCell Divisionen
dc.subjectCyclin A/biosynthesisen
dc.subjectCyclin B/biosynthesisen
dc.subjectCyclin B1en
dc.subjectCyclin-Dependent Kinase Inhibitor p16/biosynthesisen
dc.subjectCyclin-Dependent Kinase Inhibitor p27en
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphoma, B-Cell/metabolism/*pathologyen
dc.subjectLymphoma, Large B-Cell, Diffuse/metabolism/*pathologyen
dc.subjectRetinoblastoma Protein/biosynthesisen
dc.subjectTumor Suppressor Protein p53/biosynthesisen
dc.subjectTumor Suppressor Proteins/biosynthesisen
dc.titleLow expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomasen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/modpathol.3880444-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11706071-
heal.identifier.secondaryhttp://www.nature.com/modpathol/journal/v14/n11/pdf/3880444a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2001-
heal.abstractThe expression of the cyclin-dependent kinase inhibitor (CDKI) p27 protein was investigated in relation to (1) the expression of the cell cycle regulators p53, Rb and p16 and (2) the proliferation profile as determined by the expression of Ki67, cyclin A, and cyclin B1 in 80 cases of de novo diffuse large B-cell lymphomas (DLBCL). P27 expression was low/null in large tumor cells in 58/80 cases and intermediate/high in 22/80 cases. Increased expression of p53 protein was observed in 39/80 cases. Decreased expression of Rb and p16 proteins was mutually exclusive and was observed in 5/80 and 14/80 cases, respectively. The analysis of the p27 expression status (low/null versus intermediate/high) with respect to the p53 and/or Rb/p16 expression status showed that low/null p27 expression was significantly correlated with increased p53 expression (P =.018) and showed a strong trend for correlation with concurrent increased p53 expression and decreased Rb or p16 expression (P =.050). These findings suggest a tendency for concurrent alterations of the cell cycle regulators p27, p53, and Rb or p16 in DLBCL, which might result in impaired tumor growth control. Indeed, the analysis of the combined p27/p53/Rb/p16 expression status with respect to the proliferation profile showed that (1) three alterations in the combined p27/p53/Rb/p16 status (i.e., low/null P27 expression, increased expression of p53, and decreased expression of Rb or p16) were significantly correlated with increased expression of cyclin B1 (P =.005) and (2) two or three alterations were significantly correlated with increased expression of cyclin A (P =.014). These findings suggest combined impairment of a complex cell-cycle control network involving the CDK inhibitor p27, the P53 pathway, and the Rb1 pathway, which exerts a cooperative effect resulting in enhanced tumor cell proliferation.en
heal.journalNameMod Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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