Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20257
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dc.contributor.authorSchultz, R. M.en
dc.contributor.authorChirigos, M. A.en
dc.contributor.authorPavlidis, N. A.en
dc.contributor.authorYoungner, J. S.en
dc.date.accessioned2015-11-24T19:05:52Z-
dc.date.available2015-11-24T19:05:52Z-
dc.identifier.issn0361-5960-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20257-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBrucella Vaccine/isolation & purification/*pharmacologyen
dc.subjectBrucella abortus/immunologyen
dc.subjectCytotoxicity, Immunologicen
dc.subjectLipopolysaccharides/immunologyen
dc.subjectLung Neoplasms/immunology/*prevention & controlen
dc.subjectMacrophages/*immunologyen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Inbred Strainsen
dc.subjectNeoplasm Metastasis/*prevention & controlen
dc.subjectNeoplasms, Experimental/prevention & controlen
dc.titleMacrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pelen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/103619-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1978-
heal.abstractBru-Pel and Brucella abortus lipopolysaccharide (LPS) were tested for both macrophage activation and antitumor activity in an artificial metastasis model. Resting macrophages were rendered nonspecifically tumoricidal for MBL-2 lymphoblastic leukemia target cells by exposure to Bru-Pel at greater than or equal to 1 ng/ml of culture medium. B. abortus LPS failed to activate macrophages in vitro at all concentrations tested. Ip treatment of homozygous nude mice with Bru-Pel induced cytotoxic macrophages, indicating that Bru-Pel activated macrophages through a thymic-independent process. An artificial metastasis model was developed where single-cell suspensions of Madison 109 lung carcinoma were inoculated iv into syngeneic BALB/c mice. Bru-Pel, but not B. abortus LPS, strikingly inhibited tumor-colony formation in the lungs. Although Bru-Pel contains endotoxin, the data demonstrate that endotoxin is apparently not the active component by which Bru-Pel activates macrophages and enhances host resistance to cancer.en
heal.journalNameCancer Treat Repen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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