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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tzardi, M. | en |
| dc.contributor.author | Kouvidou, C. | en |
| dc.contributor.author | Papakonstantinou, E. | en |
| dc.contributor.author | Datseris, G. | en |
| dc.contributor.author | Darivianaki, K. | en |
| dc.contributor.author | Karidi, E. | en |
| dc.contributor.author | Eliopoulos, G. | en |
| dc.contributor.author | Delidis, G. | en |
| dc.contributor.author | Rontogianni, D. | en |
| dc.contributor.author | Kanavaros, P. | en |
| dc.date.accessioned | 2015-11-24T19:05:44Z | - |
| dc.date.available | 2015-11-24T19:05:44Z | - |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20234 | - |
| dc.rights | Default Licence | - |
| dc.subject | *Herpesvirus 4, Human | en |
| dc.subject | Histocompatibility Antigens Class I/*analysis | en |
| dc.subject | Histocompatibility Antigens Class II/*analysis | en |
| dc.subject | Hodgkin Disease/*immunology/*virology | en |
| dc.subject | Humans | en |
| dc.subject | In Situ Hybridization | en |
| dc.subject | RNA, Messenger/analysis | en |
| dc.subject | RNA, Viral/analysis | en |
| dc.subject | Tumor Virus Infections/*immunology | en |
| dc.subject | beta 2-Microglobulin/*analysis | en |
| dc.title | Major histocompatibility complex (MHC)-I and MHC-II expression in Hodgkin's disease in relation to the presence of Epstein-Barr Virus (EBV) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8687136 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1996 | - |
| heal.abstract | We have investigated the immunohistochemical expression of beta2-microglobulin and HLA-DR proteins in Hodgkin's disease (HD) in relation to the expression of the EBV-encoded EBER1-2 mRNAs and the LMP-1 protein. beta2-microglobulin is expressed in association with MHC-I molecules on most nucleated cells and HLA-DR belongs to the MHC-II molecules which are expressed mostly on antigen-presenting cells. Formalin-fixed paraffin embedded tissue from 39 cases of lymphonodal HD were stained by immunohistochemistry for beta2-microglobulin, HLA-DR and LMP-1 proteins and by RNA in situ hybridization for EBER1-2 mRNAs. beta2-microglobulin positive staining was found in Reed-Sternberg and Hodgkin cells (HRS cells) in 18/39 cases of HD. HLA-DR positive staining was found in HRS cells in all cases of HD. EBER1-2 transcripts and LMP-1 protein were detected in HRS cells in 16/39 cases of HD. No correlation as found between the presence of EBER 1-2 transcripts or the LMP-1 protein and the detection of beta2-microglobulin and HLA-DR proteins in HD. Thus, EBV does not seem to use downregulation of MHC-I to avoid the T-cell cytotoxic immune response in HD. In addition, EBV does not seem to be the only factor responsible for the HLA-DR expression in HRS cells of HD, although it could participate in the induction of the expression of HLA-DR molecule in the EBV positive cases of HD. | en |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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