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dc.contributor.authorBotzoris, V.en
dc.contributor.authorDrosos, A. A.en
dc.date.accessioned2015-11-24T19:05:29Z-
dc.date.available2015-11-24T19:05:29Z-
dc.identifier.issn1778-7254-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20201-
dc.rightsDefault Licence-
dc.subjectCalcium Channel Blockers/therapeutic useen
dc.subjectCardiovascular Agents/*therapeutic useen
dc.subjectEnzyme Inhibitors/therapeutic useen
dc.subjectFingersen
dc.subjectHumansen
dc.subjectPhosphodiesterase 5 Inhibitors/therapeutic useen
dc.subjectProstaglandins I/therapeutic useen
dc.subjectRaynaud Disease/*drug therapy/etiology/physiopathologyen
dc.subjectReceptors, Endothelin/antagonists & inhibitorsen
dc.subjectScleroderma, Systemic/complications/*drug therapy/physiopathologyen
dc.subjectSkin Ulcer/*drug therapy/etiology/physiopathologyen
dc.subjectSulfonamides/therapeutic useen
dc.subjectVasodilator Agents/therapeutic useen
dc.titleManagement of Raynaud's phenomenon and digital ulcers in systemic sclerosisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.jbspin.2010.11.005-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21183379-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1297319X10002952/1-s2.0-S1297319X10002952-main.pdf?_tid=b0faf6b6ec463f04ba8447959742c272&acdnat=1333523578_cf392e728e0fb0fb8ec91bc0b6ebc6d6-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractRaynaud's phenomenon (RP) and digital ulcers (DU) are the clinical manifestations of vasculopathy in systemic sclerosis. Both interfere with hand function and hold the possibility of severe complications, thus adversely influencing patients' quality of life. Managing RP and DU is often a challenge for the treating physician, who has to establish a treatment plan based upon knowledge of the current therapeutic options. The first step is to differentiate primary from secondary RP, where combining history and physical examination with diagnostic modalities, such as nailfold capillaroscopy, aids in reaching the correct diagnosis. Next a wide range of treatment options is offered nowadays, starting from first-line agents, as calcium channel blockers, to the more targeted-ones, like endothelin receptor antagonists. Research and clinical experience with each agent are reviewed in the text, as well as the combinations that more recently gain field in the treatment of DU.en
heal.journalNameJoint Bone Spineen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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