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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Baxevanis, C. N. | en |
| dc.contributor.author | Reclos, G. J. | en |
| dc.contributor.author | Economou, M. | en |
| dc.contributor.author | Arsenis, P. | en |
| dc.contributor.author | Katsiyiannis, A. | en |
| dc.contributor.author | Seferiades, K. | en |
| dc.contributor.author | Papadopoulos, G. | en |
| dc.contributor.author | Tsolas, O. | en |
| dc.contributor.author | Papamichail, M. | en |
| dc.date.accessioned | 2015-11-24T19:05:06Z | - |
| dc.date.available | 2015-11-24T19:05:06Z | - |
| dc.identifier.issn | 0892-3973 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20145 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Dose-Response Relationship, Immunologic | en |
| dc.subject | Humans | en |
| dc.subject | Interleukin-1/analysis | en |
| dc.subject | Interleukin-2/analysis | en |
| dc.subject | *Lymphocyte Culture Test, Mixed | en |
| dc.subject | Monocytes/drug effects/immunology | en |
| dc.subject | Protein Precursors/*pharmacology | en |
| dc.subject | T-Lymphocytes/drug effects/immunology | en |
| dc.subject | Thymosin/*analogs & derivatives/pharmacology | en |
| dc.subject | Time Factors | en |
| dc.title | Mechanism of action of prothymosin alpha in the human autologous mixed lymphocyte response | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.3109/08923978809006448 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2977606 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.3109/08923978809006448 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1988 | - |
| heal.abstract | Prothymosin alpha(Prot alpha), an immunologically active polypeptide derived initially from rat thymus, and now pig thymus, was tested for its effect on autoantigen-induced human T cell proliferation in vitro. Pig ProT alpha was found to enhance the autologous mixed lymphocyte response (auto-MLR). Optimum enhancement was achieved at doses which varied among different donors. Treatment of the stimulatory monocytes with ProT alpha resulted in considerably higher auto-MLR responses as compared to those with non treated monocytes. ProT alpha was without effect on T lymphocytes. In contrast, T lymphocytes exhibited enhanced proliferative activity when treated with ProT alpha in the environment of autologous monocytes. Moreover, supernatants from cultures of monocytes incubated with ProT alpha (ProT alpha-sup) were also shown to enhance the human auto-MLR either after addition in cultures or after preincubation with responder T lymphocytes. In addition, ProT alpha-sup did not demonstrate any detectable interleukin 1 (IL 1) or interleukin 2 (IL 2) - like activity. Furthermore, ProT alpha-sup induced an increase in IL 2 production in auto-MLR cultures. The enhancement of T-cell proliferation and IL 2 production by ProT alpha-sup was maximal when this material was added at the beginning of the auto-MLR, and no effect of ProT alpha-sup was seen if the latter was added 3 days after initiation of the culture. Finally, Prot alpha-sup was also shown to increase the expression of IL 2 receptors on T lymphocytes activated in the auto-MLR. These studies suggest that ProT alpha enhances the human auto-MLR through ProT alpha-sup which is released after interaction of monocytes with ProT alpha ProT alpha-sup then increases directly T lymphocyte proliferation by elevating IL 2 production and expression of IL 2 specific receptors on autoactivated T lymphocytes. | en |
| heal.journalName | Immunopharmacol Immunotoxicol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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