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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lykoudis, E. G. | en |
| dc.contributor.author | Panayotou, P. N. | en |
| dc.contributor.author | Stamatopoulos, C. N. | en |
| dc.contributor.author | Frangia, K. B. | en |
| dc.contributor.author | Papalois, A. E. | en |
| dc.contributor.author | Ioannovich, J. D. | en |
| dc.date.accessioned | 2015-11-24T19:04:22Z | - |
| dc.date.available | 2015-11-24T19:04:22Z | - |
| dc.identifier.issn | 0738-1085 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20029 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Evaluation Studies as Topic | en |
| dc.subject | Femoral Artery/injuries | en |
| dc.subject | Fibrinolytic Agents/*pharmacology | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | *Microsurgery | en |
| dc.subject | Random Allocation | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Recombinant Proteins | en |
| dc.subject | Tissue Plasminogen Activator/*pharmacology | en |
| dc.subject | Vascular Patency/*drug effects | en |
| dc.subject | *Vascular Surgical Procedures | en |
| dc.title | Microvascular repair following a modified crush-avulsion injury in a rat model: effect of recombinant human tissue-type plasminogen activator on the patency rate | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10702737 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | The failure rate of replantations following a crush-avulsion type injury is high. This study has been designed to reproduce an effective standardized crush-avulsion injury model to the femoral artery of the rat and evaluate the antithrombotic efficacy of systemic intravenous administration of recombinant human tissue-type plasminogen activator (rt-PA). The crush-avulsion injury was reproduced by using a bulldog clamp and two hemostats and followed by microvascular repair. The animals were divided into three groups of 20 rats each and received either normal saline, heparin 100 U/kg body weight, or rt-PA 3.5 mg/kg body weight intravenously. Patency tests were performed 20 min and 48 h after blood flow reestablishment. Results showed that this experimental crush-avulsion injury model ensures low patency in the control group, whereas systemic rt-PA administration improves the patency rate statistically significantly compared to control and heparin groups at both 20 min and 48 h postrevascularization. | en |
| heal.journalName | Microsurgery | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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