Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/19989Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Marselos, M. | en |
| dc.contributor.author | Lang, M. | en |
| dc.contributor.author | Torronen, R. | en |
| dc.date.accessioned | 2015-11-24T19:04:11Z | - |
| dc.date.available | 2015-11-24T19:04:11Z | - |
| dc.identifier.issn | 0009-2797 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19989 | - |
| dc.rights | Default Licence | - |
| dc.subject | Alcohol Oxidoreductases/metabolism | en |
| dc.subject | Animals | en |
| dc.subject | Disulfiram/*pharmacology | en |
| dc.subject | Ditiocarb/*pharmacology | en |
| dc.subject | Female | en |
| dc.subject | Glucosephosphate Dehydrogenase/metabolism | en |
| dc.subject | Glucuronates/*metabolism | en |
| dc.subject | Glucuronidase/metabolism | en |
| dc.subject | Glucuronosyltransferase/metabolism | en |
| dc.subject | Liver/drug effects/*enzymology | en |
| dc.subject | Phenobarbital/pharmacology | en |
| dc.subject | Pyrophosphatases/metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Sugar Acids | en |
| dc.subject | Thiocarbamates/*pharmacology | en |
| dc.subject | Uridine Diphosphate Glucose Dehydrogenase/metabolism | en |
| dc.subject | Uridine Diphosphate Glucuronic Acid | en |
| dc.title | Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. II. D-Glucuronic acid pathway | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/187353 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/0009279776901538/1-s2.0-0009279776901538-main.pdf?_tid=c368daeb54f5eb6c3a434c7893fe07a9&acdnat=1332744205_035b04cd04fbe84891786c6874410ce8 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1976 | - |
| heal.abstract | Hepatic enzymes connected with the formation and metabolism of free D-glucuronic acid were affected in rats after treatment with disulfiram or diethyldithiocarbamate (300 mg/kg, intragastrically, per day, 4 X). The activities of UDPglucose dehydrogenase, UDPglucuronic acid pyrophosphatase, UDPglucuronosyltransferase and L-gulonate dehydrogenase were enhanced, while those of glucose-6-phosphate dehydrogenase, beta-glucuronidase and D-glucuronolactone dehydrogenase were inhibited. These changes were more pronounced with disulfiram than diethyldithiocarbamate. Treatment with phenobarbital (80 mg/kg, i.p., per day, 4 X) enhanced UDP glucuronosyl-transferase, but brought about different effects on the other enzymes. Concurrent administration of phenobarbital with disulfiram or diethyldithiocarbamate led to potentiation or antagonism of the primary effects of each compound when given alone. The results suggest that activation of the D-glucuronic acid pathway may proceed in various ways, and that it is not necessarily followed by a simultaneous induction of the microsomal mixed-function oxygenase activity. | en |
| heal.journalName | Chem Biol Interact | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Marselos-1976-Modifications of dru.pdf | 665.48 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
