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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Panayiotides, J. | en |
| dc.contributor.author | Kanavaros, P. | en |
| dc.contributor.author | Protopapa, E. | en |
| dc.contributor.author | Vlachonikolis, J. | en |
| dc.contributor.author | Tzardi, M. | en |
| dc.contributor.author | Kalmanti, M. | en |
| dc.contributor.author | Delides, G. | en |
| dc.date.accessioned | 2015-11-24T19:03:45Z | - |
| dc.date.available | 2015-11-24T19:03:45Z | - |
| dc.identifier.issn | 0344-0338 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19928 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Child | en |
| dc.subject | Child, Preschool | en |
| dc.subject | Herpesviridae Infections/metabolism/*pathology | en |
| dc.subject | *Herpesvirus 4, Human | en |
| dc.subject | Hodgkin Disease/metabolism/*pathology/*virology | en |
| dc.subject | Humans | en |
| dc.subject | Tumor Virus Infections/metabolism/*pathology | en |
| dc.subject | Viral Matrix Proteins/*analysis | en |
| dc.title | Morphologic differences between latent membrane protein-1 (LMP-1)-positive and negative tumour cells in Epstein-Barr virus (EBV)-related childhood Hodgkin's disease. A morphometric study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8739467 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1996 | - |
| heal.abstract | The values of five cellular morphometric parameters (longest and shortest cytoplasmic axis, cellular circumference, area and roundness coefficient) were compared between 20 Latent Membrane Protein 1 (LMP-1)-positive and an equal number of LMP-1-negative Reed-Sternberg and Hodgkin (HRS) cells for each of 13 cases of Hodgkin's disease (HD) occurring in children (aged 3-15 years); the presence of Epstein-Barr virus (EBV) encoded EBER mRNAs had previously been detected in all cases using RNA in situ hybridisation (RISH), while the presence of LMP-1 was immunohistochemically detected using the alkaline phosphatase-antialkaline phosphatase (APAAP) method. The longest and shortest axis, circumference and area were larger in LMP-1-positive than in LMP-1 negative HRS cells, while the roundness coefficient of LMP-positive HRS cells was smaller than that of LMP-1 negative cells. All differences were statistically highly significant when univariate (paired comparisons) t-test were used. Multivariate analysis (Hotelling's T2 test) showed all differences (except the roundness coefficient) to be significant both at the 5% and 1% level of significance. These results provide a numerical basis for the alteration brought by the expression of LMP-1 in the cellular skeleton of tumour (HRS) cells in EBV-related childhood HD cases. | en |
| heal.journalName | Pathol Res Pract | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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