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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19917
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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorVlachoyiannopoulos, P. G.en
dc.contributor.authorHaidich, A. B.en
dc.contributor.authorMedsger, T. A., Jr.en
dc.contributor.authorLucas, M.en
dc.contributor.authorMichet, C. J.en
dc.contributor.authorKuwana, M.en
dc.contributor.authorYasuoka, H.en
dc.contributor.authorvan den Hoogen, F.en
dc.contributor.authorTe Boome, L.en
dc.contributor.authorvan Laar, J. M.en
dc.contributor.authorVerbeet, N. L.en
dc.contributor.authorMatucci-Cerinic, M.en
dc.contributor.authorGeorgountzos, A.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:03:37Z-
dc.date.available2015-11-24T19:03:37Z-
dc.identifier.issn0002-9343-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19917-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectDNA Topoisomerases, Type I/immunologyen
dc.subjectDatabases, Factualen
dc.subjectEsophageal Diseases/mortalityen
dc.subjectEurope/epidemiologyen
dc.subjectFemaleen
dc.subjectHeart Diseases/mortalityen
dc.subjectHumansen
dc.subjectJapan/epidemiologyen
dc.subjectKidney Diseases/mortalityen
dc.subjectLung Diseases/mortalityen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMulticenter Studies as Topicen
dc.subjectMultivariate Analysisen
dc.subjectOdds Ratioen
dc.subjectPredictive Value of Testsen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectScleroderma, Systemic/ethnology/*mortalityen
dc.subjectSurvival Rateen
dc.subjectUnited States/epidemiologyen
dc.titleMortality in systemic sclerosis: an international meta-analysis of individual patient dataen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.amjmed.2004.04.031-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15639201-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0002934304006308/1-s2.0-S0002934304006308-main.pdf?_tid=d00e2bd3e649838d5f27553a417fc63b&acdnat=1333364380_e39262478bc3d23839cae976a6be20d2-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractPURPOSE: Studies on mortality associated with systemic sclerosis have been limited by small sample sizes. We aimed to obtain large-scale evidence on survival outcomes and predictors for this disease. METHODS: We performed a meta-analysis of individual patient data from cohorts recruited from seven medical centers in the United States, Europe, and Japan, using standardized definitions for disease subtype and organ system involvement. The primary outcome was all-cause mortality. Standardized mortality ratios and predictors of mortality were estimated. The main analysis was based only on patients enrolled at each center within 6 months of diagnosis (incident cases). RESULTS: Among 1645 incident cases, 578 deaths occurred over 11,521 person-years of follow-up. Standardized mortality ratios varied by cohort (1.5 to 7.2). In multivariate analyses that adjusted for age and sex, renal (hazard ratio [HR] = 1.9; 95% confidence interval [CI]: 1.4 to 2.5), cardiac (HR = 2.8; 95% CI: 2.1 to 3.8), and pulmonary (HR = 1.6; 95% CI: 1.3 to 2.2) involvement, and anti-topoisomerase I antibodies (HR = 1.3; 95% CI: 1.0 to 1.6), increased mortality risk. Renal, cardiac, and pulmonary involvement tended to occur together (P <0.001). For patients without adverse predictors for 3 years after enrollment, the subsequent risk of death was not significantly different from that for the general population in three cohorts, but was significantly increased in three cohorts that comprised mostly referred patients. Analyses that included all cases in each center (n = 3311; total follow-up: 19,990 person-years) yielded largely similar results. CONCLUSION: Systemic sclerosis confers a high mortality risk, but there is considerable heterogeneity across settings. Internal organ involvement and anti-topoisomerase I antibodies are important determinants of mortality.en
heal.journalNameAmerican Journal of Medicineen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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