Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19857
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dc.contributor.authorJorgensen, M.en
dc.contributor.authorDaskalopoulos, G.en
dc.contributor.authorWarburton, V.en
dc.contributor.authorMitchell, H. M.en
dc.contributor.authorHazell, S. L.en
dc.date.accessioned2015-11-24T19:03:00Z-
dc.date.available2015-11-24T19:03:00Z-
dc.identifier.issn0022-1899-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19857-
dc.rightsDefault Licence-
dc.subjectBiopsyen
dc.subjectDNA, Bacterial/analysisen
dc.subjectDrug Resistance, Microbial/geneticsen
dc.subjectGenetic Variationen
dc.subjectHelicobacter Infections/*drug therapyen
dc.subjectHelicobacter pylori/*genetics/growth & developmenten
dc.subjectHumansen
dc.subjectMetronidazole/*therapeutic useen
dc.subjectPolymerase Chain Reactionen
dc.subjectStomach/microbiologyen
dc.titleMultiple strain colonization and metronidazole resistance in Helicobacter pylori-infected patients: identification from sequential and multiple biopsy specimensen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8769626-
heal.identifier.secondaryhttp://jid.oxfordjournals.org/content/174/3/631.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1996-
heal.abstractHelicobacter pylori strain diversity was investigated in infected persons by collection of multiple biopsies before and after therapy failure. It was demonstrated by random amplification of polymorphic DNA polymerase chain reaction that patients may be infected with a mixed population of H. pylori strains. Most patients were colonized with a predominant strain accompanied by up to 5 variant strains. The use of antimicrobials resulted in an altered distribution of the strains present, but the predominant strain usually remained. Patients may be infected with a mixed population of metronidazole-sensitive and -resistant strains at one time, with metronidazole-based therapy selectively enriching for a resistant population.en
heal.journalNameJ Infect Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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