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DC Field | Value | Language |
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dc.contributor.author | Sioka, C. | en |
dc.contributor.author | Exarchopoulos, T. | en |
dc.contributor.author | Tasiou, I. | en |
dc.contributor.author | Tzima, E. | en |
dc.contributor.author | Fotou, N. | en |
dc.contributor.author | Capizzello, A. | en |
dc.contributor.author | Ragos, V. | en |
dc.contributor.author | Tsekeris, P. | en |
dc.contributor.author | Fotopoulos, A. | en |
dc.date.accessioned | 2015-11-24T19:02:44Z | - |
dc.date.available | 2015-11-24T19:02:44Z | - |
dc.identifier.issn | 1748-717X | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19830 | - |
dc.rights | Default Licence | - |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Breast Neoplasms/*pathology/*radiotherapy/*surgery | en |
dc.subject | Case-Control Studies | en |
dc.subject | Chemotherapy, Adjuvant | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Organophosphorus Compounds/*pharmacology | en |
dc.subject | Organotechnetium Compounds/*pharmacology | en |
dc.subject | Postoperative Period | en |
dc.subject | Radiopharmaceuticals/*pharmacology | en |
dc.subject | Radiotherapy/*methods | en |
dc.subject | Risk Factors | en |
dc.subject | Tomography, Emission-Computed, Single-Photon/*methods | en |
dc.subject | Treatment Outcome | en |
dc.title | Myocardial perfusion imaging with (99 m)Tc-tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1186/1748-717X-6-151 | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22067743 | - |
heal.identifier.secondary | http://www.ro-journal.com/content/pdf/1748-717X-6-151.pdf | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2011 | - |
heal.abstract | PURPOSE: To evaluate the cardiac toxicity of radiotherapy (RT) in breast cancer (BC) patients employing myocardial perfusion imaging (MPI) with Tc-99 m Tetrofosmin-single photon emission computer tomography (T-SPECT). MATERIALS AND METHODS: We studied 46 BC female patients (28 patients with left and 18 patients with right BC) treated with postoperative RT compared to a control group of 85 age-matched females. The median time of RT to SPECT was 40 months (6-263). RESULTS: Abnormalities in the summed stress score (SSS) were found in 54% of left BC patients, 44.4% of right BC patients, and 32.9% of controls. In left BC patients there were significantly more SSS abnormalities compared to controls (4.0 +/- 3.5 vs 2.6 +/- 2.0, p = 0.05) and possible trend of increased abnormalities of right BC patients (3.7 +/- 3.0 vs 2.6 +/- 2.0, p = 0.14). Multiple regression analysis showed more abnormalities in the MPI of left BC patients compared to controls (SSS, p = 0.0001); Marginal toxicity was also noted in right BC patients (SSS, p = 0.045). No additional toxicity was found in patients that received adjuvant cardiotoxic chemotherapy. All T-SPECT abnormalities were clinically silent. CONCLUSION: The study suggests that radiation therapy to BC patients result in MPI abnormalities but without apparent clinical consequences. | en |
heal.journalName | Radiat Oncol | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Sioka-2011-Myocardial perfusion.pdf | 235.43 kB | Adobe PDF | View/Open |
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