Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19812
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dc.contributor.authorBoki, K. A.en
dc.contributor.authorDafni, U.en
dc.contributor.authorKarpouzas, G. A.en
dc.contributor.authorPapasteriades, C.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:02:33Z-
dc.date.available2015-11-24T19:02:33Z-
dc.identifier.issn0263-7103-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19812-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntibodies, Antineutrophil Cytoplasmic/analysisen
dc.subjectAntirheumatic Agents/therapeutic useen
dc.subjectAutoimmune Diseases/epidemiology/genetics/immunologyen
dc.subjectChurg-Strauss Syndrome/epidemiology/genetics/immunologyen
dc.subjectCyclophosphamide/therapeutic useen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGreece/epidemiologyen
dc.subjectHLA Antigens/analysis/genetics/immunologyen
dc.subjectHepatitis B Surface Antigens/analysisen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNecrosisen
dc.subjectPolyarteritis Nodosa/epidemiology/genetics/immunologyen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.subjectVasculitis/epidemiology/genetics/*immunologyen
dc.subjectWegener Granulomatosis/epidemiology/genetics/immunologyen
dc.subjectWeight Loss/physiologyen
dc.titleNecrotizing vasculitis in Greece: clinical, immunological and immunogenetic aspects. A study of 66 patientsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9374922-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1997-
heal.abstractThe clinical spectrum and outcome of necrotizing vasculitis were evaluated in a retrospective study in order to assess: (1) the clinical expression and evolution of the disease; (2) the response to several therapeutic approaches based on major events (organ involvement causing disability or death); (3) the immunogenetic background of patients. Sixty-six Greek patients fulfilling the ACR criteria for the diagnosis of vasculitis entered the study. Thirty-seven were diagnosed with Wegener's granulomatosis (WG), 22 with polyarteritis nodosa (PAN) and seven with Churg-Strauss syndrome (CSS). The demographic characteristics of patients with WG and PAN were similar. Cutaneous manifestations, gastrointestinal and peripheral nervous system involvement occurred more often in patients with PAN, whereas pulmonary and upper respiratory tract involvement, renal, ear abnormalities and fever were more frequent in patients with WG. Muscle weakness and asthma were found exclusively in patients with PAN and CSS, respectively, while the presence of classic-antineutrophil cytoplasmic antibodies (c-ANCA) characterized WG patients. Hepatitis B surface antigen (HBsAg) was found in 22% of PAN patients. No significant differences were detected when comparing the PAN and WG groups with respect to the first major event (log-rank P = 0.50) with and without potential confounders (age, gender, therapy or c-ANCA). For WG patients, a statistically significant difference was found on different routes of administration of cyclophosphamide (oral vs pulse) (P = 0.006). Regarding the HLA antigens, an increased frequency of DR1 (26.9% vs 10.3%, P = 0.057) in WG and the absence of DR3 in patients with PAN and CSS were noted. It appears that although the immunogenetic background and the clinical expression of the diseases differ, the response to treatment as well as the evolution and the survival rate of these patients are similar in the two groups.en
heal.journalNameBr J Rheumatolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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