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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19746
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dc.contributor.authorBreit, S.en
dc.contributor.authorRossler, J.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorSchweigerer, L.en
dc.date.accessioned2015-11-24T19:01:59Z-
dc.date.available2015-11-24T19:01:59Z-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19746-
dc.rightsDefault Licence-
dc.subjectActivinsen
dc.subjectAmino Acid Sequenceen
dc.subjectCell Lineen
dc.subjectClone Cellsen
dc.subjectCulture Media, Conditioned/metabolismen
dc.subjectDown-Regulation/drug effects/*physiologyen
dc.subjectGene Amplificationen
dc.subjectGenes, Reporteren
dc.subjectHumansen
dc.subjectInhibins/genetics/*metabolismen
dc.subjectKidney/cytology/*metabolismen
dc.subjectMolecular Sequence Dataen
dc.subjectNeuroblastoma/*metabolism/pathologyen
dc.subjectPeptides/metabolismen
dc.subjectPromoter Regions, Genetic/drug effectsen
dc.subject*Prostatic Secretory Proteinsen
dc.subjectProto-Oncogene Proteins c-myc/genetics/*metabolism/pharmacologyen
dc.subjectRetinoblastoma/*metabolism/pathologyen
dc.subjectSequence Analysis, Proteinen
dc.subjectTranscription, Genetic/drug effectsen
dc.subjectTransfectionen
dc.subjectTransforming Growth Factor beta/biosynthesisen
dc.titleN-myc down-regulates activin Aen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1006/bbrc.2000.3147-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10913351-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0006291X00931474/1-s2.0-S0006291X00931474-main.pdf?_tid=e7465685cdc518ab53a8df2215e6c0ae&acdnat=1332751165_afe62a25175ac1b85f62750e2479b0f3-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractN-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily. N-myc interacts with the activin A promoter, eventually inducing down-regulation of activin A mRNA and protein. This study demonstrates for the first time N-myc-induced down-regulation of a gene implicated in signal transduction. Down-regulation of activin A could deprive neuroblastomas from a signal with growth-inhibitory activities toward the tumor and its stroma and thereby permit neuroblastoma progression.en
heal.journalNameBiochem Biophys Res Communen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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