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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19745
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dc.contributor.authorHatzi, E.en
dc.contributor.authorMurphy, C.en
dc.contributor.authorZoephel, A.en
dc.contributor.authorRasmussen, H.en
dc.contributor.authorMorbidelli, L.en
dc.contributor.authorAhorn, H.en
dc.contributor.authorKunisada, K.en
dc.contributor.authorTontsch, U.en
dc.contributor.authorKlenk, M.en
dc.contributor.authorYamauchi-Takihara, K.en
dc.contributor.authorZiche, M.en
dc.contributor.authorRofstad, E. K.en
dc.contributor.authorSchweigerer, L.en
dc.contributor.authorFotsis, T.en
dc.date.accessioned2015-11-24T19:01:58Z-
dc.date.available2015-11-24T19:01:58Z-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19745-
dc.rightsDefault Licence-
dc.subjectAngiogenesis Inhibitors/metabolism/pharmacology/*physiologyen
dc.subjectAnimalsen
dc.subjectAntineoplastic Agents/metabolism/pharmacologyen
dc.subjectCattleen
dc.subjectCell Division/drug effectsen
dc.subjectCells, Cultureden
dc.subjectCentral Nervous System Neoplasms/blood supply/metabolism/pathology/therapyen
dc.subjectCornea/blood supply/drug effectsen
dc.subjectDNA-Binding Proteins/metabolismen
dc.subjectDown-Regulationen
dc.subjectEndothelium, Vascular/cytology/drug effectsen
dc.subjectFemaleen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectInterleukin-6/*metabolism/pharmacology/*physiologyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subject*Neovascularization, Pathologic/therapyen
dc.subjectNeuroblastoma/*blood supply/metabolism/pathology/therapyen
dc.subjectOncogene Protein p55(v-myc)/*genetics/metabolismen
dc.subjectRNA, Neoplasm/biosynthesisen
dc.subjectRabbitsen
dc.subjectSTAT3 Transcription Factoren
dc.subjectTrans-Activators/metabolismen
dc.subjectTransfectionen
dc.subjectTumor Cells, Cultureden
dc.titleN-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growthen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/sj.onc.1205440-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12032857-
heal.identifier.secondaryhttp://www.nature.com/onc/journal/v21/n22/pdf/1205440a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2002-
heal.abstractAngiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies. Tumor angiogenesis appears to be governed by alterations of tumor suppressor or oncogenes operant in a broad range of tumors. We have addressed this issue in neuroblastoma, a malignancy characterized by the near-exclusive amplification and overexpression of the N-Myc oncogene. Here, we report that N-Myc overexpression results in down-regulation of interleukin-6 (IL-6) and that IL-6 is an inhibitor of endothelial cell proliferation and VEGF-induced rabbit corneal angiogenesis. STAT3 is instrumental for IL-6 activity as infection with adenoviruses expressing a phosphorylation deficient STAT3 mutant renders endothelial cells insensitive to the antiproliferative action of IL-6. Finally, though IL-6 does not influence neuroblastoma cell growth, IL-6-expressing xenograft tumors in mice exhibit reduced neovascularization and suppressed growth. Our data shed new light on the mechanisms by which N-myc oncogene amplification enhances the malignant phenotype in neuroblastomas.en
heal.journalNameOncogeneen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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