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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19720
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dc.contributor.authorPurro, S. A.en
dc.contributor.authorCiani, L.en
dc.contributor.authorHoyos-Flight, M.en
dc.contributor.authorStamatakou, E.en
dc.contributor.authorSiomou, E.en
dc.contributor.authorSalinas, P. C.en
dc.date.accessioned2015-11-24T19:01:45Z-
dc.date.available2015-11-24T19:01:45Z-
dc.identifier.issn1529-2401-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19720-
dc.rightsDefault Licence-
dc.subjectAdaptor Proteins, Signal Transducing/physiologyen
dc.subjectAdenomatous Polyposis Coli Protein/deficiency/*physiologyen
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectAxons/*physiologyen
dc.subjectCells, Cultureden
dc.subjectDown-Regulation/physiologyen
dc.subjectEmbryo, Mammalianen
dc.subjectGanglia, Spinal/cytologyen
dc.subjectGrowth Cones/metabolism/physiologyen
dc.subjectMiceen
dc.subjectMice, Knockouten
dc.subjectMicrotubules/*physiologyen
dc.subjectNeuronal Plasticity/physiologyen
dc.subjectNeurons, Afferent/physiologyen
dc.subjectPhosphoproteins/physiologyen
dc.subjectProtein Isoforms/physiologyen
dc.subjectSignal Transduction/physiologyen
dc.subjectTime Factorsen
dc.subjectTransfectionen
dc.subjectWnt Proteins/*physiologyen
dc.subjectWnt3 Proteinen
dc.subjectWnt3A Proteinen
dc.subjectbeta Catenin/metabolismen
dc.titleWnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis colien
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1523/JNEUROSCI.2320-08.2008-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18716223-
heal.identifier.secondaryhttp://www.jneurosci.org/content/28/34/8644.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2008-
heal.abstractAxon guidance and target-derived signals control axonal behavior by regulating the cytoskeleton through poorly defined mechanisms. In particular, how these signaling molecules regulate the growth and directionality of microtubules is not well understood. Here we examine the effect of Wnts on growth cone remodeling, a process that precedes synapse formation. Time-lapse recordings reveal that Wnt3a rapidly inhibits growth cone translocation while inducing growth cone enlargement. These changes in axonal behavior are associated with changes in the organization of microtubules. Time-lapse imaging of EB3-GFP (green fluorescent protein)-labeled microtubule plus-ends demonstrates that Wnt3a regulates microtubule directionality, resulting in microtubule looping, growth cone pausing, and remodeling. Analyses of Dishevelled-1 (Dvl1) mutant neurons demonstrate that Dvl1 is required for Wnt-mediated microtubule reorganization and axon remodeling. Wnt signaling directly affects the microtubule cytoskeleton by unexpectedly inducing adenomatous polyposis coli (APC) loss from microtubule plus-ends. Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction.en
heal.journalNameJ Neuroscien
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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