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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kolettas, E. | en |
| dc.contributor.author | Evangelou, A. | en |
| dc.contributor.author | Gonos, E. S. | en |
| dc.date.accessioned | 2015-11-24T19:01:20Z | - |
| dc.date.available | 2015-11-24T19:01:20Z | - |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19675 | - |
| dc.rights | Default Licence | - |
| dc.subject | nu-fbr-fos | en |
| dc.subject | mammalian cells | en |
| dc.subject | cell proliferation | en |
| dc.subject | growth arrest | en |
| dc.subject | senescence | en |
| dc.subject | large-t-antigen | en |
| dc.subject | senescent human-fibroblasts | en |
| dc.subject | human-diploid fibroblasts | en |
| dc.subject | rat embryo fibroblasts | en |
| dc.subject | sv40 large t | en |
| dc.subject | c-fos | en |
| dc.subject | v-fos | en |
| dc.subject | cellular senescence | en |
| dc.subject | replicative senescence | en |
| dc.subject | life-span | en |
| dc.title | nu-FBR-fos oncogene fails to rescue mammalian cells from growth arrest but affects the responses of human fibroblasts to heparin | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://000167875900064 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2001 | - |
| heal.abstract | The effects of nu -fos oncogene on the proliferation of mammalian cells were studied using several approaches. Constitutive overexpression of nu -FBR-fos in normal human fibroblasts (MRC-5) anti of v-FBR-fos in human chondrocytes (HAC21) failed to immortalise them, extend their in vitro lifespan, increase their growth rates or induce cellular transformation. Furhter; nu -FBR-fos did not render- MRC-5 snwth factor independent or alter thier responsivensess to serum but it markedly suppressed their heparin-induced proliferation. A conditionally immortalised, temperature-sensitive rat embryo fibroblast cell line (tsa14) which undergoes growth arrest upon inactivation of a thermolabile SV40 large T antigen by a temperature shift producing a phenotype that mimick the senescent phenotype was also used to study the effects of nu -FBR-fos on cell proliferation. Whereas a wild-type SV40 large T antigen rescued tsa14 from a temperature-dependent growth arrest, v-FBR-fos failed to do so. Hence, v-FBR-fos was not sufficient to, at least, complement the tsa14 growth defect. There was no change in the expression of c-jun and junB, members of the AP-I transcriptional complex in MRC-Sv-fos cells. These darn show that nu -FBR-fos is not sufficient to rescue mammalian cells from senescence but it can affect the responses of human fibroblasts to heparin in suggesting a role of fos in cell proliferation. | en |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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