Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19667
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dc.contributor.authorKyrgiou, M.en
dc.contributor.authorKoliopoulos, G.en
dc.contributor.authorMartin-Hirsch, P.en
dc.contributor.authorArbyn, M.en
dc.contributor.authorPrendiville, W.en
dc.contributor.authorParaskevaidis, E.en
dc.date.accessioned2015-11-24T19:01:17Z-
dc.date.available2015-11-24T19:01:17Z-
dc.identifier.issn1474-547X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19667-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectBirth Weighten
dc.subjectCervical Intraepithelial Neoplasia/*therapyen
dc.subjectConizationen
dc.subjectDelivery, Obstetric/statistics & numerical dataen
dc.subjectFemaleen
dc.subjectFertilityen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectLaser Therapyen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Neoplastic/*surgeryen
dc.subjectPregnancy Outcomeen
dc.subjectUterine Cervical Neoplasms/*surgeryen
dc.titleObstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/S0140-6736(06)68181-6-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16473126-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0140673606681816/1-s2.0-S0140673606681816-main.pdf?_tid=86e3bb1f5b17e4b68f0de0f0edd89e4d&acdnat=1333714148_6e7829a810f7b131cc637d8025695580-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractBACKGROUND: Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes. In a meta-analysis, we investigated the effect of these procedures on subsequent fertility and pregnancy outcomes. METHODS: We searched for studies in MEDLINE and EMBASE and classified them by the conservative method used and the outcome measure studied regarding both fertility and pregnancy. Pooled relative risks and 95% CIs were calculated with a random-effects model and interstudy heterogeneity was assessed with Cochrane's Q test. FINDINGS: We identified 27 studies. Cold knife conisation was significantly associated with preterm delivery (<37 weeks; relative risk 2.59, 95% CI 1.80-3.72, 100/704 [14%] vs 1494/27 674 [5%]), low birthweight (<2500 g; 2.53, 1.19-5.36, 32/261 [12%] vs 905/13 229 [7%]), and caesarean section (3.17, 1.07-9.40, 31/350 [9%] vs 22/670 [3%]). Large loop excision of the transformation zone (LLETZ) was also significantly associated with preterm delivery (1.70, 1.24-2.35, 156/1402 [11%] vs 120/1739 [7%]), low birthweight (1.82, 1.09-3.06, 77/996 [8%] vs 49/1192 [4%]), and premature rupture of the membranes (2.69, 1.62-4.46, 48/905 [5%] vs 22/1038 [2%]). Similar but marginally non-significant adverse effects were recorded for laser conisation (preterm delivery 1.71, 0.93-3.14). We did not detect significantly increased risks for obstetric outcomes after laser ablation. Although severe outcomes such as admission to a neonatal intensive care unit or perinatal mortality showed adverse trends, these changes were not significant. INTERPRETATION: All the excisional procedures to treat cervical intraepithelial neoplasia present similar pregnancy-related morbidity without apparent neonatal morbidity. Caution in the treatment of young women with mild cervical abnormalities should be recommended. Clinicians now have the evidence base to counsel women appropriately.en
heal.journalNameLanceten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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