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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | van Lummel, M. | en |
| dc.contributor.author | van Veelen, P. A. | en |
| dc.contributor.author | Zaldumbide, A. | en |
| dc.contributor.author | de Ru, A. | en |
| dc.contributor.author | Janssen, G. M. | en |
| dc.contributor.author | Moustakas, A. K. | en |
| dc.contributor.author | Papadopoulos, G. K. | en |
| dc.contributor.author | Drijfhout, J. W. | en |
| dc.contributor.author | Roep, B. O. | en |
| dc.contributor.author | Koning, F. | en |
| dc.date.accessioned | 2015-11-24T19:01:16Z | - |
| dc.date.available | 2015-11-24T19:01:16Z | - |
| dc.identifier.issn | 1083-351X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19665 | - |
| dc.rights | Default Licence | - |
| dc.title | Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1074/jbc.M111.313940 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22184118 | - |
| heal.identifier.secondary | http://www.jbc.org/content/287/12/9514 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2012 | - |
| heal.abstract | HLA-DQ2 and HLA-DQ8 are strongly predisposing haplotypes for type 1 diabetes (T1D). Yet HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a transdimer formed between the alpha-chain of HLA-DQ2 (DQA1*05:01) and the beta-chain of HLA-DQ8 (DQB1*03:02). We generated cells exclusively expressing this transdimer (HLA-DQ8trans), characterized its peptide binding repertoire, and defined a unique transdimer-specific peptide binding motif that was found to be distinct from those of HLA-DQ2 and HLA-DQ8. This motif predicts an array of peptides of islet autoantigens as candidate T cell epitopes, many of which selectively bind to the HLA transdimer, whereas others bind to both HLA-DQ8 and transdimer with similar affinity. Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes. | en |
| heal.journalName | J Biol Chem | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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