Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19561
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dc.contributor.authorMakis, A.en
dc.contributor.authorPolychronopoulou, S.en
dc.contributor.authorHaidas, S.en
dc.date.accessioned2015-11-24T19:00:35Z-
dc.date.available2015-11-24T19:00:35Z-
dc.identifier.issn1077-4114-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19561-
dc.rightsDefault Licence-
dc.subjectAtaxia Telangiectasia/*complicationsen
dc.subjectBone Neoplasms/complications/*pathologyen
dc.subjectChilden
dc.subjectHumansen
dc.subjectLymphoma, Non-Hodgkin/complications/*pathologyen
dc.subjectMaleen
dc.subjectNeoplasms, Second Primary/complications/*pathologyen
dc.subjectOsteosarcoma/complications/*pathologyen
dc.titleOsteosarcoma as a second tumor after treatment for primary non-Hodgkin's lymphoma in a child with ataxia-telangiectasia: presentation of a case and review of possible pathogenetic mechanismsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15218420-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractPatients with ataxia-telangiectasia (A-T) and cancer are exposed to additional toxicity due to their underlying inability to repair chemotherapy-induced DNA damage. The authors report the development of osteosarcoma as a second neoplasia in a child with A-T who was treated, without being irradiated, for non-Hodgkin's lymphoma as a primary malignancy. This is the first report of osteosarcoma associated with A-T. The authors postulate that the mechanisms of carcinogenesis are common and independent of the different histopathology categories of these two neoplasias, and the underlying "canvas" of the A-T mutated gene was further triggered by chemotherapy, leading to the development of a second malignancy.en
heal.journalNameJ Pediatr Hematol Oncolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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