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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Makis, A. | en |
dc.contributor.author | Polychronopoulou, S. | en |
dc.contributor.author | Haidas, S. | en |
dc.date.accessioned | 2015-11-24T19:00:35Z | - |
dc.date.available | 2015-11-24T19:00:35Z | - |
dc.identifier.issn | 1077-4114 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19561 | - |
dc.rights | Default Licence | - |
dc.subject | Ataxia Telangiectasia/*complications | en |
dc.subject | Bone Neoplasms/complications/*pathology | en |
dc.subject | Child | en |
dc.subject | Humans | en |
dc.subject | Lymphoma, Non-Hodgkin/complications/*pathology | en |
dc.subject | Male | en |
dc.subject | Neoplasms, Second Primary/complications/*pathology | en |
dc.subject | Osteosarcoma/complications/*pathology | en |
dc.title | Osteosarcoma as a second tumor after treatment for primary non-Hodgkin's lymphoma in a child with ataxia-telangiectasia: presentation of a case and review of possible pathogenetic mechanisms | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15218420 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2004 | - |
heal.abstract | Patients with ataxia-telangiectasia (A-T) and cancer are exposed to additional toxicity due to their underlying inability to repair chemotherapy-induced DNA damage. The authors report the development of osteosarcoma as a second neoplasia in a child with A-T who was treated, without being irradiated, for non-Hodgkin's lymphoma as a primary malignancy. This is the first report of osteosarcoma associated with A-T. The authors postulate that the mechanisms of carcinogenesis are common and independent of the different histopathology categories of these two neoplasias, and the underlying "canvas" of the A-T mutated gene was further triggered by chemotherapy, leading to the development of a second malignancy. | en |
heal.journalName | J Pediatr Hematol Oncol | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
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