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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19533
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dc.contributor.authorFueyo, J.en
dc.contributor.authorGomez-Manzano, C.en
dc.contributor.authorYung, W. K.en
dc.contributor.authorLiu, T. J.en
dc.contributor.authorAlemany, R.en
dc.contributor.authorMcDonnell, T. J.en
dc.contributor.authorShi, X.en
dc.contributor.authorRao, J. S.en
dc.contributor.authorLevin, V. A.en
dc.contributor.authorKyritsis, A. P.en
dc.date.accessioned2015-11-24T19:00:26Z-
dc.date.available2015-11-24T19:00:26Z-
dc.identifier.issn1078-8956-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19533-
dc.rightsDefault Licence-
dc.subjectAdenoviruses, Human/geneticsen
dc.subjectAnimalsen
dc.subjectApoptosis/genetics/*physiologyen
dc.subject*Carrier Proteinsen
dc.subjectCell Cycle Proteins/genetics/physiologyen
dc.subjectCell Death/genetics/physiologyen
dc.subjectCell Survival/genetics/physiologyen
dc.subjectCyclin-Dependent Kinase Inhibitor p16/metabolismen
dc.subjectDNA-Binding Proteins/genetics/physiologyen
dc.subjectDisease Models, Animalen
dc.subjectE2F Transcription Factorsen
dc.subjectE2F1 Transcription Factoren
dc.subjectGene Expression/geneticsen
dc.subjectGene Therapyen
dc.subjectGenes, Tumor Suppressoren
dc.subjectGenetic Vectors/geneticsen
dc.subjectGlioma/*genetics/physiopathology/therapyen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subjectOncogene Protein p21(ras)/metabolismen
dc.subjectRecombinant Fusion Proteins/geneticsen
dc.subjectRetinoblastoma Protein/metabolismen
dc.subjectRetinoblastoma-Binding Protein 1en
dc.subjectTranscription Factor DP1en
dc.subjectTranscription Factors/*genetics/physiologyen
dc.subjectTransfection/geneticsen
dc.subjectTumor Cells, Cultureden
dc.titleOverexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivoen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9623977-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractThe transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective in causing apoptosis in glioma cells that retain a wild-type p53 genotype. We evaluated the effect of E2F-1 overexpression on the growth of gliomas in vitro and in vivo. In the in vitro study, the adenovirus-mediated transfer of exogenous E2F-1 protein precipitated generalized apoptosis in gliomas. The treatment with Ad5CMV-E2F-1 of nude mice carrying subcutaneous gliomas arrested tumor growth. Our results indicate that E2F-1 has anti-glioma activity in vitro and in vivo.en
heal.journalNameNat Meden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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