Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/19519Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Galaris, D. | en |
| dc.contributor.author | Pantopoulos, K. | en |
| dc.date.accessioned | 2015-11-24T19:00:22Z | - |
| dc.date.available | 2015-11-24T19:00:22Z | - |
| dc.identifier.issn | 1549-781X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19519 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Homeostasis/*physiology | en |
| dc.subject | Humans | en |
| dc.subject | Iron/*metabolism | en |
| dc.subject | Iron Chelating Agents/metabolism | en |
| dc.subject | Iron Overload/*metabolism/physiopathology | en |
| dc.subject | Liver/metabolism | en |
| dc.subject | Oxidative Stress/*physiology | en |
| dc.subject | Reactive Oxygen Species/*metabolism | en |
| dc.subject | Signal Transduction | en |
| dc.title | Oxidative stress and iron homeostasis: mechanistic and health aspects | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1080/10408360701713104 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18293179 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.1080/10408360701713104 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | Iron is an essential cofactor for important biological activities and biochemical reactions, including the transport of oxygen via red blood cells and its reduction to water during respiration. While iron's bioavailability is generally limited, pathological accumulation of the metal within tissues aggravates the generation of reactive oxygen species (ROS) and elicits toxic effects, which are mainly related to oxidative stress. Here, we describe the role of iron in ROS-induced toxicity and discuss molecular mechanisms and physiological aspects of ROS- and iron-mediated signaling. In addition, we review our current understanding of the regulation of iron homeostasis at the cellular and systemic levels, and focus on the pathogenesis and management of iron overload disorders. | en |
| heal.journalName | Crit Rev Clin Lab Sci | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License
