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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19514
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dc.contributor.authorTsoumpou, I.en
dc.contributor.authorArbyn, M.en
dc.contributor.authorKyrgiou, M.en
dc.contributor.authorWentzensen, N.en
dc.contributor.authorKoliopoulos, G.en
dc.contributor.authorMartin-Hirsch, P.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorParaskevaidis, E.en
dc.date.accessioned2015-11-24T19:00:20Z-
dc.date.available2015-11-24T19:00:20Z-
dc.identifier.issn1532-1967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19514-
dc.rightsDefault Licence-
dc.subject*Alphapapillomavirusen
dc.subjectBiological Markers/analysisen
dc.subjectBiopsyen
dc.subjectCervical Intraepithelial Neoplasia/chemistry/diagnosisen
dc.subjectCervix Uteri/*chemistry/pathology/virologyen
dc.subjectColposcopyen
dc.subjectCyclin-Dependent Kinase Inhibitor p16/*analysisen
dc.subjectCytological Techniques/utilizationen
dc.subjectFemaleen
dc.subjectHistological Techniques/utilizationen
dc.subjectHumansen
dc.subjectImmunohistochemistry/utilizationen
dc.subjectNeoplasm Proteins/analysisen
dc.subjectPapillomavirus Infections/*diagnosis/metabolismen
dc.subjectPredictive Value of Testsen
dc.subjectProspective Studiesen
dc.subjectResearch Designen
dc.subjectRetrospective Studiesen
dc.subjectTumor Markers, Biological/analysisen
dc.subjectUterine Cervical Dysplasia/metabolism/virologyen
dc.subjectUterine Cervical Neoplasms/*chemistry/diagnosis/virologyen
dc.subjectUterine Cervicitis/*diagnosis/metabolismen
dc.subjectVaginal Smearsen
dc.titlep16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.ctrv.2008.10.005-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19261387-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0305737208002958/1-s2.0-S0305737208002958-main.pdf?_tid=927e3f7531ab275f0e1fcac1c5354ea1&acdnat=1333714015_88398090b595f729a78c78ef55337b18-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractBACKGROUND: P16(INK4a) is a biomarker for transforming HPV infections that could act as an adjunct to current cytological and histological assessment of cervical smears and biopsies, allowing the identification of those women with ambiguous results that require referral to colposcopy and potentially treatment. MATERIAL AND METHODS: We conducted a systematic review of all studies that evaluated the use of p16(INK4a) in cytological or histological specimens from the uterine cervix. We also estimated the mean proportion of samples that were positive for p16(INK4a) in cytology and histology, stratified by the grade of the lesion. RESULTS: Sixty-one studies were included. The proportion of cervical smears overexpressing p16(INK4a) increased with the severity of cytological abnormality. Among normal smears, only 12% (95% CI: 7-17%) were positive for the biomarker compared to 45% of ASCUS and LSIL (95% CI: 35-54% and 37-57%, respectively) and 89% of HSIL smears (95% CI: 84-95%). Similarly, in histology only 2% of normal biopsies (95% CI: 0.4-30%) and 38% of CIN1 (95% CI: 23-53%) showed diffuse staining for p16(INK4a) compared to 68% of CIN2 (95% CI: 44-92%) and 82% of CIN3 (95% CI: 72-92%). CONCLUSION: Although there is good evidence that p16(INK4a) immunostaining correlates with the severity of cytological/histological abnormalities, the reproducibility is limited due to insufficiently standardized interpretation of the immunostaining. Therefore, a consensus needs to be reached regarding the evaluation of p16(INK4a) staining and the biomarker needs to be assessed in various clinical settings addressing specific clinical questions.en
heal.journalNameCancer Treat Reven
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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