Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19491
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dc.contributor.authorKosmidis, P. A.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorEleftheraki, A. G.en
dc.contributor.authorKalofonos, H. P.en
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorSkarlos, D.en
dc.contributor.authorDimopoulos, M. A.en
dc.contributor.authorBafaloukos, D.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorBoukovinas, J.en
dc.contributor.authorLambaki, S.en
dc.contributor.authorKatirtzoglou, N.en
dc.contributor.authorBakogiannis, C.en
dc.contributor.authorSyrigos, K. N.en
dc.date.accessioned2015-11-24T19:00:10Z-
dc.date.available2015-11-24T19:00:10Z-
dc.identifier.issn1569-8041-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19491-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic useen
dc.subjectCarcinoma, Non-Small-Cell Lung/*drug therapy/pathologyen
dc.subjectDeoxycytidine/administration & dosage/adverse effects/*analogs &en
dc.subjectderivatives/therapeutic useen
dc.subjectDisease-Free Survivalen
dc.subjectDrug Administration Scheduleen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectLung Neoplasms/*drug therapy/pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPaclitaxel/administration & dosage/adverse effects/*therapeutic useen
dc.subjectVinblastine/administration & dosage/adverse effects/*analogs &en
dc.subjectderivatives/therapeutic useen
dc.titlePaclitaxel and gemcitabine versus paclitaxel and vinorelbine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group (HeCOG)en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1093/annonc/mdq445-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20880999-
heal.identifier.secondaryhttp://annonc.oxfordjournals.org/content/22/4/827.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractBACKGROUND: Paclitaxel (Taxol) and vinorelbine have shown synergism of cytotoxic effects in vitro and clinical activity in phase I and II studies. This combination was compared prospectively with the paclitaxel/gemcitabine regimen in non-operable non-small-cell lung cancer. PATIENTS AND METHODS: Chemotherapy-naive patients, stage IIIbwet and IV with performance status (0-1), were randomized to receive paclitaxel 200 mg/m(2) on day 1 plus gemcitabine 1 gm/m(2) (group A) on days 1 and 8 every 3 weeks or paclitaxel 80 mg/m(2) plus vinorelbine 22.5 mg/m(2) (group B) on days 1, 8 and 15 every 4 weeks. RESULTS: A total of 398 out of 415 patients were eligible for analysis on intent-to-treat basis (group A: 196, group B: 202). Progression-free survival (PFS) was 5.0 months [95% confidence interval (CI) 4.3-5.6] and 4.4 months (95% CI 3.7-5.2) for groups A and B respectively (P=0.365). Median survival was 11.1 months (95% CI 9.2-13.0) and 8.6 months (95% CI 7.0-10.2) for groups A and B respectively (P = 0.147). Grade 3/4 neutropenia and leukopenia were worse in group B (P<0.001, in both cases). Febrile neutropenia and severe infections were more prominent (P<0.001, P=0.029 respectively) in group B. CONCLUSION: Although response rate, PFS and survival were non-different in both groups, toxicity was significantly worse in group B and therefore further investigation of P-Vin is of no value.en
heal.journalNameAnn Oncolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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