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DC Field | Value | Language |
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dc.contributor.author | Ioannidis, J. P. | en |
dc.contributor.author | Abrams, E. J. | en |
dc.contributor.author | Ammann, A. | en |
dc.contributor.author | Bulterys, M. | en |
dc.contributor.author | Goedert, J. J. | en |
dc.contributor.author | Gray, L. | en |
dc.contributor.author | Korber, B. T. | en |
dc.contributor.author | Mayaux, M. J. | en |
dc.contributor.author | Mofenson, L. M. | en |
dc.contributor.author | Newell, M. L. | en |
dc.contributor.author | Shapiro, D. E. | en |
dc.contributor.author | Teglas, J. P. | en |
dc.contributor.author | Wilfert, C. M. | en |
dc.date.accessioned | 2015-11-24T18:59:36Z | - |
dc.date.available | 2015-11-24T18:59:36Z | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19385 | - |
dc.rights | Default Licence | - |
dc.subject | Anti-HIV Agents/therapeutic use | en |
dc.subject | Clinical Trials as Topic | en |
dc.subject | Europe | en |
dc.subject | Female | en |
dc.subject | Gestational Age | en |
dc.subject | HIV Infections/drug therapy/*transmission/virology | en |
dc.subject | HIV-1/*physiology | en |
dc.subject | Humans | en |
dc.subject | Infant, Newborn | en |
dc.subject | *Infectious Disease Transmission, Vertical | en |
dc.subject | International Cooperation | en |
dc.subject | Pregnancy | en |
dc.subject | Pregnancy Complications, Infectious/drug therapy/*virology | en |
dc.subject | Prospective Studies | en |
dc.subject | RNA, Viral/*blood | en |
dc.subject | Registries | en |
dc.subject | Risk Factors | en |
dc.subject | United States | en |
dc.subject | *Viral Load | en |
dc.subject | Viremia | en |
dc.title | Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1086/318530 | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11170978 | - |
heal.identifier.secondary | http://jid.oxfordjournals.org/content/183/4/539.full.pdf | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2001 | - |
heal.abstract | In a collaboration of 7 European and United States prospective studies, 44 cases of vertical human immunodeficiency virus type 1 (HIV-1) transmission were identified among 1202 women with RNA virus loads <1000 copies/mL at delivery or at the measurement closest to delivery. For mothers receiving antiretroviral treatment during pregnancy or at the time of delivery (or both), there was a 1.0% transmission rate (8 of 834; 95% confidence interval [CI], 0.4%-1.9%), compared with 9.8% (36 of 368; 95% CI, 7.0%-13.4%) for untreated mothers (risk ratio, 0.10; 95% CI, 0.05-0.21). In multivariate analysis adjusting for study, transmission was lower with antiretroviral treatment (odds ratio [OR], 0.10; P<.001), cesarean section (OR, 0.30; P=.022), greater birth weight (P=.003), and higher CD4 cell count (P=.039). In 12 of 44 cases, multiple RNA measurements were obtained during pregnancy or at the time of delivery or within 4 months after giving birth; in 10 of the 12 cases, the geometric mean virus load was >500 copies/mL. Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia. | en |
heal.journalName | J Infect Dis | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Ioannidis-2001-Perinatal transmissi.pdf | 92.41 kB | Adobe PDF | View/Open Request a copy |
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