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https://olympias.lib.uoi.gr/jspui/handle/123456789/19322Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pavlidis, N. | en |
| dc.contributor.author | Nicolaides, C. | en |
| dc.contributor.author | Athanassiadis, A. | en |
| dc.contributor.author | Beriatou, K. | en |
| dc.contributor.author | Skarlos, D. | en |
| dc.contributor.author | Giannakakis, T. | en |
| dc.contributor.author | Kosmidis, P. | en |
| dc.contributor.author | Karvounis, N. | en |
| dc.contributor.author | Fountzilas, G. | en |
| dc.date.accessioned | 2015-11-24T18:58:54Z | - |
| dc.date.available | 2015-11-24T18:58:54Z | - |
| dc.identifier.issn | 0030-2414 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19322 | - |
| dc.rights | Default Licence | - |
| dc.subject | Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use | en |
| dc.subject | Colorectal Neoplasms/*drug therapy | en |
| dc.subject | Female | en |
| dc.subject | Fluorouracil/administration & dosage/adverse effects | en |
| dc.subject | Humans | en |
| dc.subject | Interferon-gamma/administration & dosage/adverse effects | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neoplasm Metastasis | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Phase II study of 5-fluorouracil and interferon-gamma in patients with metastatic colorectal cancer. A Hellenic Cooperative Oncology Group Study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8604243 | - |
| heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000227553 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1996 | - |
| heal.abstract | Preclinical data have shown a synergism between 5-fluorouracil and interferon-gamma against human colon carcinoma cell lines. We conducted a phase II trial of this combination in 34 patients with metastatic colorectal cancer. 5-Fluorouracil was administered as an intravenous bolus of 500 mg/m2 weekly and interferon-gamma subcutaneous injection at a dose of 200 micrograms (6 x 10(6) IU) 3 times a week. Thirty-two patients were evaluable for response. There was one complete and two partial responses (response rate 9.0%, 95% CI 1.98-25.02%). Eleven patients (34%) had stable disease. Common toxicities included fever 81%, nausea/vomiting 19%, diarrhea 16%, flu-like syndrome 16%, malaise 12.5% and leukopenia 12.5%. These results indicate that the above combination of 5-fluorouracil and interferon-gamma has an unimpressive activity in patients with advanced colorectal carcinoma. Toxicity was very tolerable. | en |
| heal.journalName | Oncology | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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