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dc.contributor.authorFotsis, T.en
dc.contributor.authorPepper, M. S.en
dc.contributor.authorMontesano, R.en
dc.contributor.authorAktas, E.en
dc.contributor.authorBreit, S.en
dc.contributor.authorSchweigerer, L.en
dc.contributor.authorRasku, S.en
dc.contributor.authorWahala, K.en
dc.contributor.authorAdlercreutz, H.en
dc.date.accessioned2015-11-24T18:58:27Z-
dc.date.available2015-11-24T18:58:27Z-
dc.identifier.issn0950-351X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19281-
dc.rightsDefault Licence-
dc.subjectCell Division/drug effectsen
dc.subjectEndothelium, Vascular/cytologyen
dc.subjectEstrogens, Non-Steroidal/pharmacology/*therapeutic useen
dc.subjectGenistein/pharmacologyen
dc.subjectHumansen
dc.subject*Isoflavonesen
dc.subjectNeoplasms/pathologyen
dc.subjectNeovascularization, Pathologic/*prevention & controlen
dc.subjectPhytoestrogensen
dc.subjectPlant Preparationsen
dc.titlePhytoestrogens and inhibition of angiogenesisen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10384818-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0950351X98800098/1-s2.0-S0950351X98800098-main.pdf?_tid=10be425a0c49034531497e0535a6f968&acdnat=1332751552_db6f82f0e526a7ae5fceb8c8168fe494-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractThe consumption of a plant-based diet can prevent the development and progression of chronic diseases associated with extensive neovascularization, including the progression and growth of solid malignant tumours. We have previously shown that the plant-derived isoflavonoid genistein is a potent inhibitor of cell proliferation and in vitro angiogenesis. Moreover, the concentration of genistein in the urine of subjects consuming a plant-based diet is 30-fold higher than that in subjects consuming a traditional Western diet. We have also reported that certain structurally related flavonoids are more potent inhibitors than genistein. Indeed, 3-hydroxyflavone, 3',4'-dihydroxyflavone, 2',3'-dihydroxyflavone, fisetin, apigenin and luteolin inhibit the proliferation of normal and tumour cells as well as in vitro angiogenesis at half-maximal concentrations in the lower micromolar range. The wide distribution of isoflavonoids and flavonoids in the plant kingdom, together with their anti-angiogenic and anti-mitotic properties, suggest that these phytoestrogens may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumours.en
heal.journalNameBaillieres Clin Endocrinol Metaben
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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