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https://olympias.lib.uoi.gr/jspui/handle/123456789/19275Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Papathanassiou, K. | en |
| dc.contributor.author | Naka, K. K. | en |
| dc.contributor.author | Kazakos, N. | en |
| dc.contributor.author | Kanioglou, C. | en |
| dc.contributor.author | Makriyiannis, D. | en |
| dc.contributor.author | Pappas, K. | en |
| dc.contributor.author | Katsouras, C. S. | en |
| dc.contributor.author | Liveris, K. | en |
| dc.contributor.author | Kolettis, T. | en |
| dc.contributor.author | Tsatsoulis, A. | en |
| dc.contributor.author | Michalis, L. K. | en |
| dc.date.accessioned | 2015-11-24T18:58:24Z | - |
| dc.date.available | 2015-11-24T18:58:24Z | - |
| dc.identifier.issn | 1879-1484 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19275 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Blood Glucose/metabolism | en |
| dc.subject | Diabetes Mellitus, Type 2/*drug therapy | en |
| dc.subject | Endothelium, Vascular/*drug effects | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Hypoglycemic Agents/therapeutic use | en |
| dc.subject | Insulin Resistance | en |
| dc.subject | Male | en |
| dc.subject | Metformin/therapeutic use | en |
| dc.subject | Middle Aged | en |
| dc.subject | Sulfonylurea Compounds/*therapeutic use | en |
| dc.subject | Thiazolidinediones/*therapeutic use | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.atherosclerosis.2008.11.027 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19135671 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0021915008008411/1-s2.0-S0021915008008411-main.pdf?_tid=432e7f32fe766702610c0511a746e1ae&acdnat=1333969737_a0ef08da311b591d5bd9216ef71f05cf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | OBJECTIVE: The aim of this study was to compare the effect of glimepiride and pioglitazone on endothelial function in patients with type 2 diabetes already on metformin. METHODS: Twenty-eight patients with type 2 diabetes already on metformin, without known cardiovascular disease, were randomized in 2 groups; glimepiride (4 mg od) was added in group A (n=14) and pioglitazone (30 mg od) in group B (n=14) for 6 months. Flow-mediated dilation (FMD) in the brachial artery was assessed in all patients, at baseline and at follow-up. RESULTS: The 2 groups did not differ in age (mean+/-S.D., 63.6+/-7.3 years vs 62.8+/-7.2 years respectively), or any measured variable at baseline. Fasting glucose and glycated haemoglobin improved similarly in both groups. There were significant differences between the 2 groups in the absolute changes observed at follow-up in waist circumference, +1.86+/-3.11 cm vs -1.86+/-1.88 cm in groups A and B respectively; fasting insulin levels, +14.79+/-12.56 pmol/L vs -25.84+/-28.09 pmol/L; homeostasis model assessment (HOMA), +0.66+/-1.01 vs -1.83+/-1.38; HDL cholesterol levels, -0.07+/-0.22 mmol/L vs +0.14+/-0.20 mmol/L and FMD, +0.14+/-1.09% vs +2.02+/-2.05% (p<0.05 for all). The only independent predictor factor of the FMD improvement was treatment-induced changes in HOMA (R(2): 0.488, slope: -0.782, [95% CI: -1.128, -0.436], p=0.0001). CONCLUSIONS: In patients with type 2 diabetes already on metformin, addition of pioglitazone as compared to glimepiride, improved endothelial function despite similar glycemic control. The improvement in endothelial function was mainly due to a reduction in insulin resistance. | en |
| heal.journalName | Atherosclerosis | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Papathanassiou-2009-Pioglitazone vs glim.pdf | 220.14 kB | Adobe PDF | View/Open Request a copy |
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