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https://olympias.lib.uoi.gr/jspui/handle/123456789/19269Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Voutetakis, A. | en |
| dc.contributor.author | Sertedaki, A. | en |
| dc.contributor.author | Livadas, S. | en |
| dc.contributor.author | Xekouki, P. | en |
| dc.contributor.author | Bossis, I. | en |
| dc.contributor.author | Dacou-Voutetakis, C. | en |
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.date.accessioned | 2015-11-24T18:58:21Z | - |
| dc.date.available | 2015-11-24T18:58:21Z | - |
| dc.identifier.issn | 0391-4097 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19269 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Child | en |
| dc.subject | Child, Preschool | en |
| dc.subject | Homeodomain Proteins/*genetics | en |
| dc.subject | Humans | en |
| dc.subject | Magnetic Resonance Imaging | en |
| dc.subject | Male | en |
| dc.subject | Organ Size | en |
| dc.subject | Pituitary Diseases/genetics/pathology/*physiopathology | en |
| dc.subject | Pituitary Gland/*pathology | en |
| dc.subject | Pituitary Hormones/*deficiency | en |
| dc.title | Pituitary size fluctuation in long-term MR studies of PROP1 deficient patients: A persistent pathophysiological mechanism? | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16794371 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2006 | - |
| heal.abstract | Inactivating PROP1 gene alterations are responsible for over 50% of familial combined pituitary hormone deficiency cases. Pituitary enlargement followed by regression and subnormal pituitary size has been documented in a number of PROP1 deficient patients. Data derived from PROP1 deficient mice (Ames dwarfs) have revealed some of the underlying cellular mechanisms. Nevertheless, long-term magnetic resonance imaging (MRI) findings in two PROP1 deficient patients suggest the evolution of pituitary pathology as more complex and persistent than previously described. Patient A had enlarged pituitary gland (pituitary height: 9-10 mm), demonstrated by serial MRI carried out from age 5 to 8.5 yr, small pituitary gland (4 mm) at age 10 yr and pituitary enlargement (11 mm) at age 19 yr. Patient B had a pituitary gland of normal size at age 7 yr (5 mm), whereas at age 14.3 and 16.3 yr, an enlarged pituitary gland was disclosed (10 and 11 mm, respectively). Both series of events are suggestive of a persistent pathophysiological mechanism in the pituitary gland of patients with PROP1 gene defects. Therefore, long-term pituitary follow-up by MRI in such patients may be necessary even in the case of a small or normal pituitary gland. It must be noted that current data from the Ames dwarf mouse cannot fully explain the observed pituitary size fluctuation. | en |
| heal.journalName | Journal of Endocrinological Investigation | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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