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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19249
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dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorDemertzis, M. A.en
dc.contributor.authorMiller, J. R.en
dc.contributor.authorPapadopoulou, C.en
dc.contributor.authorDodorou, C.en
dc.contributor.authorFilousis, G.en
dc.date.accessioned2015-11-24T18:58:08Z-
dc.date.available2015-11-24T18:58:08Z-
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19249-
dc.rightsDefault Licence-
dc.subjectAnti-Bacterial Agentsen
dc.subjectAnti-Infective Agents/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectAntifungal Agents/chemical synthesis/chemistry/pharmacologyen
dc.subjectAntineoplastic Agents/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectCandida albicans/drug effectsen
dc.subjectCrystallography, X-Rayen
dc.subjectEscherichia coli/drug effectsen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectMolecular Structureen
dc.subjectOrganoplatinum Compounds/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectSpectrophotometryen
dc.subjectStaphylococcus aureus/drug effectsen
dc.subjectThiosemicarbazones/*chemical synthesis/chemistry/*pharmacologyen
dc.titlePlatinum(II) complexes with 2-acetyl pyridine thiosemicarbazone. Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activityen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11566327-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0162013401002240/1-s2.0-S0162013401002240-main.pdf?_tid=abd3ff9ad741d693b60980f5b6ea3681&acdnat=1332846536_ab85441cd98f854a14ff38881b41a38c-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2001-
heal.abstractAn interesting series of new platinum complexes has been synthesized by the reaction of Na(2)PtCl(4) with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)Cl], [Pt(HAcTsc)(2)]Cl(2) and [Pt(AcTsc)(2)], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)Cl] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH-Cl), pi-pi and weak Pt-Pt and Pt-pi contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(II) complexes, [Pd(AcTsc)Cl], [Pd(HAcTsc)(2)]Cl(2) and [Pd(AcTsc)(2)], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram- bacteria. Additionally, the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] while the rest, display marginal cytogenetic and antitumour effects.en
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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