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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19209
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dc.contributor.authorThomas, D.en
dc.contributor.authorLiakos, V.en
dc.contributor.authorVassiliou, E.en
dc.contributor.authorHatzimarkou, F.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorKaldrimides, P.en
dc.date.accessioned2015-11-24T18:57:48Z-
dc.date.available2015-11-24T18:57:48Z-
dc.identifier.issn1720-8386-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19209-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAutoantibodies/biosynthesis/*blooden
dc.subjectChilden
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectIodide Peroxidase/*immunologyen
dc.subjectIodine Radioisotopes/*therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRetrospective Studiesen
dc.subjectSurvival Rateen
dc.subjectThyroglobulin/*immunologyen
dc.subjectThyroid Neoplasms/immunology/mortality/pathology/*surgeryen
dc.subject*Thyroidectomyen
dc.titlePossible reasons for different pattern disappearance of thyroglobulin and thyroid peroxidase autoantibodies in patients with differentiated thyroid carcinoma following total thyroidectomy and iodine-131 ablationen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17505148-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractThe purpose of this study was to reveal some possible factors for the differences between the pattern of disappearance of thyroglobulin autoantibodies (anti-Tg) and thyroid peroxidase autoantibodies (anti-TPO) in patients with differentiated thyroid carcinoma following thyroidectomy and iodine-131 ablation. Patients with a history of follicular cell derived cancer (papillary, follicular, both papillary and follicular, Hurthle cell) and high pre-operative titers of anti-TPO and/or anti-Tg autoantibodies were retrospectively studied. Thyroglobulin (Tg) levels were measured using radio-immunometric assay (RIA). Anti-Tg and anti-TPO levels during the first 6 yr' follow-up were measured by passive agglutination, during the following 10 yr by ELISA method and during the last 2 yr by chemiluminescence assay. A statistically significant difference was observed between median time (72 months) of disappearance of anti-TPO and median time (39 months) of disappearance of anti-Tg in patients with complete ablation of thyroid tissue, following iodine-131 administration (p=0.0395, Logrank statistic=4.24, Kaplan-Meier method). A statistically significant difference was observed between median time (106 months) of disappearance of anti-TPO and median time (33 months) of disappearance of anti-Tg in patients >45 yr of age (p=0.034) and between median time (111 months) of disappearance of anti-TPO and median time (41 months) of disappearance of anti-Tg in patients with tumor size <2 cm (p=0.0175). We concluded that patients with differentiated thyroid carcinoma and pre-surgical elevated titers of both Tg and anti-TPO tend to become earlier anti-Tg seronegative. Although tumor size and age may influence the pattern of thyroid autoantibody reduction, the exact reasons for the different rhythm of autoantibodies decrease must further be evaluated.en
heal.journalNameJournal of Endocrinological Investigationen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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